Structure of human glutamate carboxypeptidase II. The fold of this catalytic domain is related to aminopeptidases from Aeromonas proteolytica. The catalytic site of this protease contains two Zn atoms (shown as a golden spheres). Zinc 1 is complexed by Glu425 and His553, whereas zinc 2 is complexed by His337 and Asp387. On the other hand, Asp387 and a water molecule form "bridges" and complex both Zn atoms. According to its position, the putative general base which attacks the target peptidic bond depends on Glu424.
Structures are rendered as ribbons. Catalytic and catalytic metal-complexing residues are shown as neons. Inhibitors are displayed as space filling spheres.
Carbons are shown in light gray, hydrogens in cyan, oxygens in red, nitrogens in blue, and sulfurs in yellow.
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