Proteases are a diverse and important group of enzymes representing >2% of the human, chimpanzee, mouse and rat genomes. This group of enzymes is implicated in numerous physiological processes. The importance of proteases is illustrated by the existence of 129 different hereditary diseases due to mutations in protease genes. Furthermore, proteases have been implicated in multiple human pathologies, including vascular diseases, rheumatoid arthritis, neurodegenerative processes, and cancer. During the last ten years, our laboratory has identified and characterized more than 60 human protease genes.
Due to the importance of proteolytic enzymes in human physiology and pathology, we have recently introduced the concept of Degradome, as the complete repertoire of proteases expressed by a tissue or organism. Thanks to the recent completion of the human, chimpanzee, mouse, and rat genome sequencing projects, we were able to analyze and compare for the first time the well as complete protease repertoire in those mammalian organisms, as the complement of protease inhibitor genes. This webpage is a repository of this information, as described in The Degradome database: expanding roles of mammalian proteases in life and disease Nucleic Acids Res (2015).
This webpage also contains the Supplementary Material of Human and mouse proteases: a comparative genomic approach Nat Rev Genet (2003) 4: 544-558, Genome sequence of the brown Norway rat yields insights into mammalian evolution Nature (2004) 428: 493-521, A genomic analysis of rat proteases and protease inhibitors Genome Res. (2004) 14: 609-622, and Comparative genomic analysis of human and chimpanzee proteases Genomics (2005) 86: 638-647.
The aim of this webpage is to provide an updated version of human, chimpanzee, mouse, and rat proteases and protease inhibitors, as well as as the growing number of hereditary diseases caused by mutations in protease genes.Analysis of the human and mouse genomes has allowed us to annotate 588 human, 587 chimpanzee, 672 mouse, and 658 rat protease genes. Proteases are classified in five different classes according to their mechanism of catalysis. Follow the links on the left to browse each protease class.
7, Jan (2016) - New entry in "Diseases": Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease.
8, Jan (2016) - Several modifications in "Diseases" concerning CANDLE/PRAAS syndrome, including the union of 2 existing entries, and the adition of some new mutations: Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production.