Human, Mouse and Rat Degradomes in Numbers

This table summarizes the total number of protease genes in the human, mouse and rat genomes, including orthologous genes, and human-, mouse- or rat-specific genes. Some functional genes have been inactivated by deleterious mutations in one species, and they are mentioned, although they are not included in the final count.
Catalytic class
Total Aspartic Cysteine Metallo Serine Threonine
Human proteases 588 21 164 192 184 27
Rat proteases 658 24 176 200 229 29
Mouse proteases 672 27 181 208 230 26
Rat/Human orthologs 555 21 151 187 170 26
Rat/Mouse orthologs 615 24 167 199 199 26
Human specific 21 0 9 3 8 1
Rat specific 40 0 8 1 28 3
Rodent specific 38 2 15 5 16 0
Human gene/Rat pseudogene 8 0 3 2 3 0
Rat gene/Human pseudogene 23 1 1 7 14 0
Mouse gene/Rat pseudogene 12 1 3 4 4 0
Rat gene/Mouse pseudogene 2 0 1 0 1 0