Selected publications from our lab

Lopez-Otin, C., Galluzzi, L., Freije, J. M., Madeo, F. and Kroemer, G. Metabolic Control of Longevity. Cell166802-21 (2016).  PubMed
Osorio, F. G., Soria-Valles, C., Santiago-Fernandez, O., Bernal, T., Mittelbrunn, M., Colado, E., Rodriguez, F., Bonzon-Kulichenko, E., Vazquez, J., Porta-de-la-Riva, M., Ceron, J., Fueyo, A., Li, J., Green, A. R., Freije, J. M. and Lopez-Otin, C. Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling. Nature Med2291-6 (2016).  PubMed
Puente, X. S., et al. Non-coding recurrent mutations in chronic lymphocytic leukaemia. Nature526519-24 (2015).  PubMed
Soria-Valles, C., Osorio, F. G., Gutierrez-Fernandez, A., De Los Angeles, A., Bueno, C., Menendez, P., Martin-Subero, J. I., Daley, G. Q., Freije, J. M. and Lopez-Otin, C. NF-kappaB activation impairs somatic cell reprogramming in ageing. Nature Cell Biol171004-13 (2015).  PubMed
Quiros, P. M., Langer, T. and Lopez-Otin, C. New roles for mitochondrial proteases in health, ageing and disease. Nature Rev Mol Cell Biol16345-59 (2015).  PubMed
Robles-Espinoza, C. D.,et al. POT1 loss-of-function variants predispose to familial melanoma. Nature Genet46478-81 (2014).  PubMed
Gordon, L. B., Rothman, F. G., Lopez-Otin, C. and Misteli, T. Progeria: a paradigm for translational medicine. Cell156400-7 (2014).  PubMed
Marmoset Genome Sequencing and Analysis Consortium. The common marmoset genome provides insight into primate biology and evolution. Nature Genet46850-7 (2014).  PubMed
Fanjul-Fernandez, M., Quesada, V., Cabanillas, R., Cadinanos, J., Fontanil, T., Obaya, A., Ramsay, A. J., Llorente, J. L., Astudillo, A., Cal, S. and Lopez-Otin, C. Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas. Nature Commun42531 (2013).  PubMed
Alexandrov, L. B., et al. Signatures of mutational processes in human cancer. Nature500415-21 (2013).  PubMed
de la Rosa, J., Freije, J. M., Cabanillas, R., Osorio, F. G., Fraga, M. F., Fernandez-Garcia, M. S., Rad, R., Fanjul, V., Ugalde, A. P., Liang, Q., Prosser, H. M., Bradley, A., Cadinanos, J. and Lopez-Otin, C. Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion. Nature Commun42268 (2013).  PubMed
Lapuente-Brun, E., Moreno-Loshuertos, R., Acin-Perez, R., Latorre-Pellicer, A., Colas, C., Balsa, E., Perales-Clemente, E., Quiros, P. M., Calvo, E., Rodriguez-Hernandez, M. A., Navas, P., Cruz, R., Carracedo, A., Lopez-Otin, C., Perez-Martos, A., Fernandez-Silva, P., Fernandez-Vizarra, E. and Enriquez, J. A. Supercomplex assembly determines electron flux in the mitochondrial electron transport chain. Science3401567-70 (2013).  PubMed
Lopez-Otin, C., Blasco, M. A., Partridge, L., Serrano, M. and Kroemer, G. The hallmarks of aging. Cell1531194-217 (2013).  PubMed
Ramsay, A. J., Quesada, V., Foronda, M., Conde, L., Martinez-Trillos, A., Villamor, N., Rodriguez, D., Kwarciak, A., Garabaya, C., Gallardo, M., Lopez-Guerra, M., Lopez-Guillermo, A., Puente, X. S., Blasco, M. A., Campo, E. and Lopez-Otin, C. POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia. Nature Genet45526-30 (2013).  PubMed
Puente, X. S. and Lopez-Otin, C. The evolutionary biography of chronic lymphocytic leukemia. Nature Genet45229-31 (2013).  PubMed
Quesada, V., et al. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nature Genet4447-52 (2012).  PubMed
Puente, X. S., et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature475101-5 (2011).  PubMed
Puente, X. S., Quesada, V., Osorio, F. G., Cabanillas, R., Cadinanos, J., Fraile, J. M., Ordonez, G. R., Puente, D. A., Gutierrez-Fernandez, A., Fanjul-Fernandez, M., Levy, N., Freije, J. M. and Lopez-Otin, C. Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome. Am J Hum Genet88650-6 (2011).  PubMed
Locke, D. P., et al. Comparative and demographic analysis of orang-utan genomes. Nature469529-33 (2011).  PubMed
Warren, W. C., et al. The genome of a songbird. Nature464757-62 (2010).  PubMed
Lopez-Otin, C. and Hunter, T. The regulatory crosstalk between kinases and proteases in cancer. Nature Rev Cancer10278-92 (2010).  PubMed
International Cancer Genome Consortium. International network of cancer genome projects. Nature464993-8 (2010).  PubMed
Quesada, V., Ordonez, G. R., Sanchez, L. M., Puente, X. S. and Lopez-Otin, C. The Degradome database: mammalian proteases and diseases of proteolysis. Nucleic Acids Res37D239-43 (2009).  PubMed
Varela, I., Pereira, S., Ugalde, A. P., Navarro, C. L., Suarez, M. F., Cau, P., Cadinanos, J., Osorio, F. G., Foray, N., Cobo, J., de Carlos, F., Levy, N., Freije, J. M. and Lopez-Otin, C. Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging. Nature Med14767-72 (2008).  PubMed
Warren, W. C., et al. Genome analysis of the platypus reveals unique signatures of evolution. Nature453175-83 (2008).  PubMed
Espada, J., Varela, I., Flores, I., Ugalde, A. P., Cadinanos, J., Pendas, A. M., Stewart, C. L., Tryggvason, K., Blasco, M. A., Freije, J. M. and Lopez-Otin, C. Nuclear envelope defects cause stem cell dysfunction in premature-aging mice. J Cell Biol18127-35 (2008).  PubMed
Lopez-Otin, C. and Bond, J. S. Proteases: multifunctional enzymes in life and disease. J Biol Chem28330433-7 (2008).  PubMed
Lopez-Otin, C. and Matrisian, L. M. Emerging roles of proteases in tumour suppression. Nature Rev Cancer7800-8 (2007).  PubMed
Marino, G., Salvador-Montoliu, N., Fueyo, A., Knecht, E., Mizushima, N. and Lopez-Otin, C. Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem28218573-83 (2007).  PubMed
Varela, I., Cadinanos, J., Pendas, A. M., Gutierrez-Fernandez, A., Folgueras, A. R., Sanchez, L. M., Zhou, Z., Rodriguez, F. J., Stewart, C. L., Vega, J. A., Tryggvason, K., Freije, J. M. and Lopez-Otin, C. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature437564-8 (2005).  PubMed
Liu, B., Wang, J., Chan, K. M., Tjia, W. M., Deng, W., Guan, X., Huang, J. D., Li, K. M., Chau, P. Y., Chen, D. J., Pei, D., Pendas, A. M., Cadinanos, J., Lopez-Otin, C., Tse, H. F., Hutchison, C., Chen, J., Cao, Y., Cheah, K. S., Tryggvason, K. and Zhou, Z. Genomic instability in laminopathy-based premature aging. Nature Med11780-5 (2005).  PubMed
Chimpanzee Sequencing and Analysis Consortium. Initial sequence of the chimpanzee genome and comparison with the human genome. Nature43769-87 (2005).  PubMed
Rat Genome Sequencing Project Consortium. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature428493-521 (2004).  PubMed
Balbin, M., Fueyo, A., Tester, A. M., Pendas, A. M., Pitiot, A. S., Astudillo, A., Overall, C. M., Shapiro, S. D. and Lopez-Otin, C. Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nature Genet35252-7 (2003).  PubMed
Puente, X. S., Sanchez, L. M., Overall, C. M. and Lopez-Otin, C. Human and mouse proteases: a comparative genomic approach. Nature Rev Genet4544-58 (2003).  PubMed
Cal, S., Quesada, V., Garabaya, C. and Lopez-Otin, C. Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. Proc Natl Acad Sci U S A1009185-90 (2003).  PubMed
Pendas, A. M., Zhou, Z., Cadinanos, J., Freije, J. M., Wang, J., Hultenby, K., Astudillo, A., Wernerson, A., Rodriguez, F., Tryggvason, K. and Lopez-Otin, C. Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nature Genet3194-9 (2002).  PubMed
Lopez-Otin, C. and Overall, C. M. Protease degradomics: a new challenge for proteomics. Nature Rev Mol Cell Biol3509-19 (2002).  PubMed
Overall, C. M. and Lopez-Otin, C. Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nature Rev Cancer2657-72 (2002).  PubMed
Freije, J. M., Diez-Itza, I., Balbin, M., Sanchez, L. M., Blasco, R., Tolivia, J. and Lopez-Otin, C. Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas. J Biol Chem26916766-73 (1994).  PubMed

Recent publications

2017

de la Rosa, J., Weber, J., Friedrich, M. J., Li, Y., Rad, L., Ponstingl, H., Liang, Q., de Quiros, S. B., Noorani, I., Metzakopian, E., Strong, A., Li, M. A., Astudillo, A., Fernandez-Garcia, M. T., Fernandez-Garcia, M. S., Hoffman, G. J., Fuente, R., Vassiliou, G. S., Rad, R., Lopez-Otin, C., Bradley, A. and Cadinanos, J. A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes. Nature Genet (2017).  PubMed
Fraile, J. M., Campos-Iglesias, D. and Freije, J. M. Deubiquitination in cancer stem cells. Aging (Albany NY)9297-298 (2017).  PubMed
Fraile, J. M., Manchado, E., Lujambio, A., Quesada, V., Campos-Iglesias, D., Webb, T. R., Lowe, S. W., Lopez-Otin, C. and Freije, J. M. USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer. J Biol Chem2924164-4175 (2017).  PubMed
Lopez-Otin, C. and Marino, G. Tagged ATG8-Coding Constructs for the In Vitro and In Vivo Assessment of ATG4 Activity. Methods Enzymol587189-205 (2017).  PubMed

2016

Marques, P. I., Fonseca, F., Carvalho, A. S., Puente, D. A., Damiao, I., Almeida, V., Barros, N., Barros, A., Carvalho, F., Azkargorta, M., Elortza, F., Osorio, H., Matthiesen, R., Quesada, V. and Seixas, S. Sequence variation at KLK and WFDC clusters and its association to semen hyperviscosity and other male infertility phenotypes. Hum Reprod312881-2891 (2016).  PubMed
Reinstein, E., Gutierrez-Fernandez, A., Tzur, S., Bormans, C., Marcu, S., Tayeb-Fligelman, E., Vinkler, C., Raas-Rothschild, A., Irge, D., Landau, M., Shohat, M., Puente, X. S., Behar, D. M. and Lopez-Otin, C. Congenital dilated cardiomyopathy caused by biallelic mutations in Filamin C. Eur J Hum Genet241792-1796 (2016).  PubMed
Mateo, F., Arenas, E. J., Aguilar, H., Serra-Musach, J., de Garibay, G. R., Boni, J., Maicas, M., Du, S., Iorio, F., Herranz-Ors, C., Islam, A., Prado, X., Llorente, A., Petit, A., Vidal, A., Catala, I., Soler, T., Venturas, G., Rojo-Sebastian, A., Serra, H., Cuadras, D., Blanco, I., Lozano, J., Canals, F., Sieuwerts, A. M., de Weerd, V., Look, M. P., Puertas, S., Garcia, N., Perkins, A. S., Bonifaci, N., Skowron, M., Gomez-Baldo, L., Hernandez, V., Martinez-Aranda, A., Martinez-Iniesta, M., Serrat, X., Ceron, J., Brunet, J., Barretina, M. P., Gil, M., Falo, C., Fernandez, A., Morilla, I., Pernas, S., Pla, M. J., Andreu, X., Segui, M. A., Ballester, R., Castella, E., Nellist, M., Morales, S., Valls, J., Velasco, A., Matias-Guiu, X., Figueras, A., Sanchez-Mut, J. V., Sanchez-Cespedes, M., Cordero, A., Gomez-Miragaya, J., Palomero, L., Gomez, A., Gajewski, T. F., Cohen, E. E., Jesiotr, M., Bodnar, L., Quintela-Fandino, M., Lopez-Bigas, N., Valdes-Mas, R., Puente, X. S., Vinals, F., Casanovas, O., Graupera, M., Hernandez-Losa, J., Ramon Y Cajal, S., Garcia-Alonso, L., Saez-Rodriguez, J., Esteller, M., Sierra, A., Martin-Martin, N., Matheu, A., Carracedo, A., Gonzalez-Suarez, E., Nanjundan, M., Cortes, J., Lazaro, C., Odero, M. D., Martens, J. W., Moreno-Bueno, G., Barcellos-Hoff, M. H., Villanueva, A., Gomis, R. R. and Pujana, M. A. Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition. Oncogene (2016).  PubMed
Abascal, F., Corvelo, A., Cruz, F., Villanueva-Canas, J. L., Vlasova, A., Marcet-Houben, M., Martinez-Cruz, B., Cheng, J. Y., Prieto, P., Quesada, V., Quilez, J., Li, G., Garcia, F., Rubio-Camarillo, M., Frias, L., Ribeca, P., Capella-Gutierrez, S., Rodriguez, J. M., Camara, F., Lowy, E., Cozzuto, L., Erb, I., Tress, M. L., Rodriguez-Ales, J. L., Ruiz-Orera, J., Reverter, F., Casas-Marce, M., Soriano, L., Arango, J. R., Derdak, S., Galan, B., Blanc, J., Gut, M., Lorente-Galdos, B., Andres-Nieto, M., Lopez-Otin, C., Valencia, A., Gut, I., Garcia, J. L., Guigo, R., Murphy, W. J., Ruiz-Herrera, A., Marques-Bonet, T., Roma, G., Notredame, C., Mailund, T., Alba, M. M., Gabaldon, T., Alioto, T. and Godoy, J. A. Extreme genomic erosion after recurrent demographic bottlenecks in the highly endangered Iberian lynx. Genome Biol17251 (2016).  PubMed
Rivera-Torres, J., Calvo, C. J., Llach, A., Guzman-Martinez, G., Caballero, R., Gonzalez-Gomez, C., Jimenez-Borreguero, L. J., Guadix, J. A., Osorio, F. G., Lopez-Otin, C., Herraiz-Martinez, A., Cabello, N., Vallmitjana, A., Benitez, R., Gordon, L. B., Jalife, J., Perez-Pomares, J. M., Tamargo, J., Delpon, E., Hove-Madsen, L., Filgueiras-Rama, D. and Andres, V. Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations. Proc Natl Acad Sci U S A113E7250-E7259 (2016).  PubMed
Fraile, J. M., Campos-Iglesias, D., Rodriguez, F., Espanol, Y. and Freije, J. M. The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis. Oncotarget774427-74434 (2016).  PubMed
Soria-Valles, C., Lopez-Soto, A., Osorio, F. G. and Lopez-Otin, C. Immune and inflammatory responses to DNA damage in cancer and aging. Mech Ageing Dev (2016).  PubMed
Lee, S. J., Jung, Y. S., Yoon, M. H., Kang, S. M., Oh, A. Y., Lee, J. H., Jun, S. Y., Woo, T. G., Chun, H. Y., Kim, S. K., Chung, K. J., Lee, H. Y., Lee, K., Jin, G., Na, M. K., Ha, N. C., Barcena, C., Freije, J. M., Lopez-Otin, C., Song, G. Y. and Park, B. J. Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype. J Clin Invest1263879-3893 (2016).  PubMed
Kandaswamy, R., Sava, G. P., Speedy, H. E., Bea, S., Martin-Subero, J. I., Studd, J. B., Migliorini, G., Law, P. J., Puente, X. S., Martin-Garcia, D., Salaverria, I., Gutierrez-Abril, J., Lopez-Otin, C., Catovsky, D., Allan, J. M., Campo, E. and Houlston, R. S. Genetic Predisposition to Chronic Lymphocytic Leukemia Is Mediated by a BMF Super-Enhancer Polymorphism. Cell Rep162061-7 (2016).  PubMed
Lopez-Otin, C., Galluzzi, L., Freije, J. M., Madeo, F. and Kroemer, G. Metabolic Control of Longevity. Cell166802-21 (2016).  PubMed
Valdes-Mas, R., Gutierrez-Abril, J., Pitiot, A. S., Santamaria, I., Puente, D. A., Muniz Lobato, S., Balbin, M. and Puente, X. S. Transplacental transfer of essential thrombocythemia in monozygotic twins. Blood (2016).  PubMed
Selman, M., Lopez-Otin, C. and Pardo, A. Age-driven developmental drift in the pathogenesis of idiopathic pulmonary fibrosis. Eur Respir J (2016).  PubMed
Soria-Valles, C. and Lopez-Otin, C. iPSCs: On the Road to Reprogramming Aging. Trends Mol Med (2016).  PubMed
Carrero, D., Soria-Valles, C. and Lopez-Otin, C. Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells. Dis Model Mech9719-35 (2016).  PubMed
Santiago-Fernandez, O., Osorio, F. G. and Lopez-Otin, C. Proteostasis alterations in myeloproliferative neoplasms: oncogenic relevance and therapeutic opportunities. Exp Hematol (2016).  PubMed
Soria-Valles, C., Gutierrez-Fernandez, A., Osorio, F. G., Carrero, D., Ferrando, A. A., Colado, E., Fernandez-Garcia, M. S., Bonzon-Kulichenko, E., Vazquez, J., Fueyo, A. and Lopez-Otin, C. MMP-25 Metalloprotease Regulates Innate Immune Response through NF-kappaB Signaling. J Immunol197296-302 (2016).  PubMed
Soria-Valles, C., Carrero, D., Gabau, E., Velasco, G., Quesada, V., Barcena, C., Moens, M., Fieggen, K., Mohrcken, S., Owens, M., Puente, D. A., Asensio, O., Loeys, B., Perez, A., Benoit, V., Wuyts, W., Levy, N., Hennekam, R. C., De Sandre-Giovannoli, A. and Lopez-Otin, C. Novel LMNA mutations cause an aggressive atypical neonatal progeria without progerin accumulation. J Med Genet (2016).  PubMed
Nadeu, F., Delgado, J., Royo, C., Baumann, T., Stankovic, T., Pinyol, M., Jares, P., Navarro, A., Martin-Garcia, D., Bea, S., Salaverria, I., Oldreive, C., Aymerich, M., Suarez-Cisneros, H., Rozman, M., Villamor, N., Colomer, D., Lopez-Guillermo, A., Gonzalez, M., Alcoceba, M., Terol, M. J., Colado, E., Puente, X. S., Lopez-Otin, C., Enjuanes, A. and Campo, E. Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1 and ATM mutations in chronic lymphocytic leukemia. Blood (2016).  PubMed
Loi, M., Cenni, V., Duchi, S., Squarzoni, S., Lopez-Otin, C., Foisner, R., Lattanzi, G. and Capanni, C. Barrier-to-autointegration factor (BAF) involvement in prelamin A-related chromatin organization changes. Oncotarget715662-77 (2016).  PubMed
Adhikari, K., Fontanil, T., Cal, S., Mendoza-Revilla, J., Fuentes-Guajardo, M., Chacon-Duque, J. C., Al-Saadi, F., Johansson, J. A., Quinto-Sanchez, M., Acuna-Alonzo, V., Jaramillo, C., Arias, W., Barquera Lozano, R., Macin Perez, G., Gomez-Valdes, J., Villamil-Ramirez, H., Hunemeier, T., Ramallo, V., Silva de Cerqueira, C. C., Hurtado, M., Villegas, V., Granja, V., Gallo, C., Poletti, G., Schuler-Faccini, L., Salzano, F. M., Bortolini, M. C., Canizales-Quinteros, S., Rothhammer, F., Bedoya, G., Gonzalez-Jose, R., Headon, D., Lopez-Otin, C., Tobin, D. J., Balding, D. and Ruiz-Linares, A. A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features. Nature Commun710815 (2016).  PubMed
Mur, P., Sanchez-Cuartielles, E., Ausso, S., Aiza, G., Valdes-Mas, R., Pineda, M., Navarro, M., Brunet, J., Urioste, M., Lazaro, C., Moreno, V., Capella, G., Puente, X. S. and Valle, L. Scarce evidence of the causal role of germline mutations in UNC5C in hereditary colorectal cancer and polyposis. Sci Rep620697 (2016).  PubMed
Korwitz, A., Merkwirth, C., Richter-Dennerlein, R., Troder, S. E., Sprenger, H. G., Quiros, P. M., Lopez-Otin, C., Rugarli, E. I. and Langer, T. Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol212157-66 (2016).  PubMed
Multiple authors including Fernández, AF., López-Otín, C., and Mariño, G.  Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy121-222 (2016).  PubMed
Osorio, F. G., Freije, J. M. and Lopez-Otin, C. The novel tumor suppressor AIRAPL regulates IGF1R proteostasis. Cell Cycle15873-4 (2016).  PubMed
Valdes-Mas, R., Gutierrez-Abril, J., Puente, X. S. and Lopez-Otin, C. Chronic lymphocytic leukemia: looking into the dark side of the genome. Cell Death Differ237-9 (2016).  PubMed
Osorio, F. G., Soria-Valles, C., Santiago-Fernandez, O., Freije, J. M. and Lopez-Otin, C. NF-kappaB signaling as a driver of ageing. Int Rev Cell Mol Biol326133-74 (2016).  PubMed
Osorio, F. G., Soria-Valles, C., Santiago-Fernandez, O., Bernal, T., Mittelbrunn, M., Colado, E., Rodriguez, F., Bonzon-Kulichenko, E., Vazquez, J., Porta-de-la-Riva, M., Ceron, J., Fueyo, A., Li, J., Green, A. R., Freije, J. M. and Lopez-Otin, C. Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling. Nature Med2291-6 (2016).  PubMed

2015

Loi, M., Cenni, V., Duchi, S., Squarzoni, S., Lopez-Otin, C., Foisner, R., Lattanzi, G. and Capanni, C. Barrier-to-autointegration factor (BAF) involvement in prelamin A-related chromatin organization changes. Oncotarget715662-77 (2016).  PubMed
Alioto, T. S., et al. A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing. Nature Commun610001 (2015).  PubMed
Puente, X. S., et al. Non-coding recurrent mutations in chronic lymphocytic leukaemia. Nature526519-24 (2015).  PubMed
Xargay-Torrent, S., Lopez-Guerra, M., Rosich, L., Montraveta, A., Roldan, J., Rodriguez, V., Villamor, N., Aymerich, M., Lagisetti, C., Webb, T. R., Lopez-Otin, C., Campo, E. and Colomer, D. The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia. Oncotarget622734-49 (2015).  PubMed
Soria-Valles, C., Osorio, F. G., Gutierrez-Fernandez, A., De Los Angeles, A., Bueno, C., Menendez, P., Martin-Subero, J. I., Daley, G. Q., Freije, J. M. and Lopez-Otin, C. NF-kappaB activation impairs somatic cell reprogramming in ageing. Nature Cell Biol171004-13 (2015).  PubMed
Gutierrez-Fernandez, A., Soria-Valles, C., Osorio, F. G., Gutierrez-Abril, J., Garabaya, C., Aguirre, A., Fueyo, A., Fernandez-Garcia, M. S., Puente, X. S. and Lopez-Otin, C. Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid. EMBO J341875-88 (2015).  PubMed
Rodriguez, D., Bretones, G., Quesada, V., Villamor, N., Arango, J. R., Lopez-Guillermo, A., Ramsay, A. J., Baumann, T., Quiros, P. M., Navarro, A., Royo, C., Martin-Subero, J. I., Campo, E. and Lopez-Otin, C. Mutations in CHD2 cause defective association with active chromatin in chronic lymphocytic leukemia. Blood126195-202 (2015).  PubMed
Quiros, P. M., Langer, T. and Lopez-Otin, C. New roles for mitochondrial proteases in health, ageing and disease. Nature Rev Mol Cell Biol16345-59 (2015).  PubMed
Cal, S. and Lopez-Otin, C. ADAMTS proteases and cancer. Matrix Biol44-46C77-85 (2015).  PubMed
Cabrera, S., Maciel, M., Herrera, I., Nava, T., Vergara, F., Gaxiola, M., Lopez-Otin, C., Selman, M. and Pardo, A. Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis. Autophagy11670-84 (2015).  PubMed
Aguilera, O., Gonzalez-Sancho, J. M., Zazo, S., Rincon, R., Fernandez, A. F., Tapia, O., Canals, F., Morte, B., Calvanese, V., Orgaz, J. L., Niell, N., Aguilar, S., Freije, J. M., Grana, O., Pisano, D. G., Borrero, A., Martinez-Useros, J., Jimenez, B., Fraga, M. F., Garcia-Foncillas, J., Lopez-Otin, C., Lafarga, M., Rojo, F. and Munoz, A. Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer. Oncotarget65903-17 (2015).  PubMed
Wallace, D. F., Secondes, E. S., Rishi, G., Ostini, L., McDonald, C. J., Lane, S. W., Vu, T., Hooper, J. D., Velasco, G., Ramsay, A. J., Lopez-Otin, C. and Subramaniam, V. N. A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction. Br J Haematol168891-901 (2015).  PubMed
Rodriguez, D., Bretones, G., Arango, J. R., Valdespino, V., Campo, E., Quesada, V. and Lopez-Otin, C. Molecular pathogenesis of CLL and its evolution. Int J Hematol101219-28 (2015).  PubMed
Bassaganyas, L., Bea, S., Escaramis, G., Tornador, C., Salaverria, I., Zapata, L., Drechsel, O., Ferreira, P. G., Rodriguez-Santiago, B., Tubio, J. M., Navarro, A., Martin-Garcia, D., Lopez, C., Martinez-Trillos, A., Lopez-Guillermo, A., Gut, M., Ossowski, S., Lopez-Otin, C., Campo, E. and Estivill, X. Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by longitudinal genomic analysis. Leukemia29758 (2015).  PubMed
Queiros, A. C., Villamor, N., Clot, G., Martinez-Trillos, A., Kulis, M., Navarro, A., Penas, E. M., Jayne, S., Majid, A., Richter, J., Bergmann, A. K., Kolarova, J., Royo, C., Russinol, N., Castellano, G., Pinyol, M., Bea, S., Salaverria, I., Lopez-Guerra, M., Colomer, D., Aymerich, M., Rozman, M., Delgado, J., Gine, E., Gonzalez-Diaz, M., Puente, X. S., Siebert, R., Dyer, M. J., Lopez-Otin, C., Rozman, C., Campo, E., Lopez-Guillermo, A. and Martin-Subero, J. I. A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact. Leukemia29598-605 (2015).  PubMed
Keane, M., Semeiks, J., Webb, A. E., Li, Y. I., Quesada, V., Craig, T., Madsen, L. B., van Dam, S., Brawand, D., Marques, P. I., Michalak, P., Kang, L., Bhak, J., Yim, H. S., Grishin, N. V., Nielsen, N. H., Heide-Jorgensen, M. P., Oziolor, E. M., Matson, C. W., Church, G. M., Stuart, G. W., Patton, J. C., George, J. C., Suydam, R., Larsen, K., Lopez-Otin, C., O'Connell, M. J., Bickham, J. W., Thomsen, B. and de Magalhaes, J. P. Insights into the evolution of longevity from the bowhead whale genome. Cell Rep10112-22 (2015).  PubMed
Caravia, X. M. and Lopez-Otin, C. Regulatory Roles of miRNAs in Aging. Adv Exp Med Biol887213-30 (2015).  PubMed
Soria-Valles, C., Osorio, F. G. and Lopez-Otin, C. Reprogramming aging through DOT1L inhibition. Cell Cycle143345-6 (2015).  PubMed
Galluzzi, L., et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ2258-73 (2015).  PubMed
Fernandez, A. F. and Lopez-Otin, C. The functional and pathologic relevance of autophagy proteases. J Clin Invest12533-41 (2015).  PubMed
Lopez-Guerra, M., Xargay-Torrent, S., Rosich, L., Montraveta, A., Roldan, J., Matas-Cespedes, A., Villamor, N., Aymerich, M., Lopez-Otin, C., Perez-Galan, P., Roue, G., Campo, E. and Colomer, D. The gamma-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells. Leukemia2996-106 (2015).  PubMed

2014

Moncunill, V., Gonzalez, S., Bea, S., Andrieux, L. O., Salaverria, I., Royo, C., Martinez, L., Puiggros, M., Segura-Wang, M., Stutz, A. M., Navarro, A., Royo, R., Gelpi, J. L., Gut, I. G., Lopez-Otin, C., Orozco, M., Korbel, J. O., Campo, E., Puente, X. S. and Torrents, D. Comprehensive characterization of complex structural variations in cancer by directly comparing genome sequence reads. Nature Biotechnol321106-12 (2014).  PubMed
Valdes-Mas, R., Gutierrez-Fernandez, A., Gomez, J., Coto, E., Astudillo, A., Puente, D. A., Reguero, J. R., Alvarez, V., Moris, C., Leon, D., Martin, M., Puente, X. S. and Lopez-Otin, C. Mutations in filamin C cause a new form of familial hypertrophic cardiomyopathy. Nature Commun55326 (2014).  PubMed
Baixauli, F., Lopez-Otin, C. and Mittelbrunn, M. Exosomes and autophagy: coordinated mechanisms for the maintenance of cellular fitness. Front Immunol5403 (2014).  PubMed
Soria-Valles, C., Gutierrez-Fernandez, A., Guiu, M., Mari, B., Fueyo, A., Gomis, R. R. and Lopez-Otin, C. The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21. Oncogene333054-63 (2014).  PubMed
Foley, C. J., Fanjul-Fernandez, M., Bohm, A., Nguyen, N., Agarwal, A., Austin, K., Koukos, G., Covic, L., Lopez-Otin, C. and Kuliopulos, A. Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis. Oncogene332264-72 (2014).  PubMed
Marmoset Genome Sequencing and Analysis Consortium. The common marmoset genome provides insight into primate biology and evolution. Nature Genet46850-7 (2014).  PubMed
Quiros, P. M., Espanol, Y., Acin-Perez, R., Rodriguez, F., Barcena, C., Watanabe, K., Calvo, E., Loureiro, M., Fernandez-Garcia, M. S., Fueyo, A., Vazquez, J., Enriquez, J. A. and Lopez-Otin, C. ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity. Cell Rep8542-56 (2014).  PubMed
Porlan, E., Marti-Prado, B., Morante-Redolat, J. M., Consiglio, A., Delgado, A. C., Kypta, R., Lopez-Otin, C., Kirstein, M. and Farinas, I. MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin. Nature Cell Biol16629-38 (2014).  PubMed
Willemetz, A., Lenoir, A., Deschemin, J. C., Lopez-Otin, C., Ramsay, A. J., Vaulont, S. and Nicolas, G. Matriptase-2 is essential for hepcidin repression during fetal life and postnatal development in mice to maintain iron homeostasis. Blood124441-4 (2014).  PubMed
Barcena, C., Quesada, V., De Sandre-Giovannoli, A., Puente, D. A., Fernandez-Toral, J., Sigaudy, S., Baban, A., Levy, N., Velasco, G. and Lopez-Otin, C. Exome sequencing identifies a novel mutation in PIK3R1 as the cause of SHORT syndrome. BMC Med Genet1551 (2014).  PubMed
Martinez-Trillos, A., Pinyol, M., Navarro, A., Aymerich, M., Jares, P., Juan, M., Rozman, M., Colomer, D., Delgado, J., Gine, E., Gonzalez-Diaz, M., Hernandez-Rivas, J. M., Colado, E., Rayon, C., Payer, A. R., Terol, M. J., Navarro, B., Quesada, V., Puente, X. S., Rozman, C., Lopez-Otin, C., Campo, E., Lopez-Guillermo, A. and Villamor, N. Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome. Blood1233790-6 (2014).  PubMed
Lopez-Guerra, M., Xargay-Torrent, S., Rosich, L., Montraveta, A., Roldan, J., Matas-Cespedes, A., Villamor, N., Aymerich, M., Lopez-Otin, C., Perez-Galan, P., Roue, G., Campo, E. and Colomer, D. The gamma-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells. Leukemia2996-106 (2015).  PubMed
Gonzalez-Granado, J. M., Silvestre-Roig, C., Rocha-Perugini, V., Trigueros-Motos, L., Cibrian, D., Morlino, G., Blanco-Berrocal, M., Osorio, F. G., Freije, J. M., Lopez-Otin, C., Sanchez-Madrid, F. and Andres, V. Nuclear envelope lamin-A couples actin dynamics with immunological synapse architecture and T cell activation. Sci Signal7ra37 (2014).  PubMed
Santacruz, R., Villamor, N., Aymerich, M., Martinez-Trillos, A., Lopez, C., Navarro, A., Rozman, M., Bea, S., Royo, C., Cazorla, M., Colomer, D., Gine, E., Pinyol, M., Puente, X. S., Lopez-Otin, C., Campo, E., Lopez-Guillermo, A. and Delgado, J. The prognostic impact of minimal residual disease in patients with chronic lymphocytic leukemia requiring first-line therapy. Haematologica99873-80 (2014).  PubMed
Robles-Espinoza, C. D.,et al. POT1 loss-of-function variants predispose to familial melanoma. Nature Genet46478-81 (2014).  PubMed
Xiao, X., Hu, Y., Quiros, P. M., Wei, Q., Lopez-Otin, C. and Dong, Z. OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury. Am J Physiol Renal Physiol306F1318-26 (2014).  PubMed
Llobet-Navas, D., Rodriguez-Barrueco, R., Castro, V., Ugalde, A. P., Sumazin, P., Jacob-Sendler, D., Demircan, B., Castillo-Martin, M., Putcha, P., Marshall, N., Villagrasa, P., Chan, J., Sanchez-Garcia, F., Pe'er, D., Rabadan, R., Iavarone, A., Cordon-Cardo, C., Califano, A., Lopez-Otin, C., Ezhkova, E. and Silva, J. M. The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland. Genes Dev28765-82 (2014).  PubMed
Marino, G., Pietrocola, F., Eisenberg, T., Kong, Y., Malik, S. A., Andryushkova, A., Schroeder, S., Pendl, T., Harger, A., Niso-Santano, M., Zamzami, N., Scoazec, M., Durand, S., Enot, D. P., Fernandez, A. F., Martins, I., Kepp, O., Senovilla, L., Bauvy, C., Morselli, E., Vacchelli, E., Bennetzen, M., Magnes, C., Sinner, F., Pieber, T., Lopez-Otin, C., Maiuri, M. C., Codogno, P., Andersen, J. S., Hill, J. A., Madeo, F. and Kroemer, G. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell53710-25 (2014).  PubMed
Gordon, L. B., Rothman, F. G., Lopez-Otin, C. and Misteli, T. Progeria: a paradigm for translational medicine. Cell156400-7 (2014).  PubMed
Ferreira, P. G., Jares, P., Rico, D., Gomez-Lopez, G., Martinez-Trillos, A., Villamor, N., Ecker, S., Gonzalez-Perez, A., Knowles, D. G., Monlong, J., Johnson, R., Quesada, V., Djebali, S., Papasaikas, P., Lopez-Guerra, M., Colomer, D., Royo, C., Cazorla, M., Pinyol, M., Clot, G., Aymerich, M., Rozman, M., Kulis, M., Tamborero, D., Gouin, A., Blanc, J., Gut, M., Gut, I., Puente, X. S., Pisano, D. G., Martin-Subero, J. I., Lopez-Bigas, N., Lopez-Guillermo, A., Valencia, A., Lopez-Otin, C., Campo, E. and Guigo, R. Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia. Genome Res24212-26 (2014).  PubMed

2013

Villamor, N., Lopez-Guillermo, A., Lopez-Otin, C. and Campo, E. Next-generation sequencing in chronic lymphocytic leukemia. Semin Hematol50286-95 (2013).  PubMed
Fraile, J. M., Ordonez, G. R., Quiros, P. M., Astudillo, A., Galvan, J. A., Colomer, D., Lopez-Otin, C., Freije, J. M. and Puente, X. S. Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas. Oncotarget41931-2 (2013).  PubMed
Bea, S., Valdes-Mas, R., Navarro, A., Salaverria, I., Martin-Garcia, D., Jares, P., Gine, E., Pinyol, M., Royo, C., Nadeu, F., Conde, L., Juan, M., Clot, G., Vizan, P., Di Croce, L., Puente, D. A., Lopez-Guerra, M., Moros, A., Roue, G., Aymerich, M., Villamor, N., Colomo, L., Martinez, A., Valera, A., Martin-Subero, J. I., Amador, V., Hernandez, L., Rozman, M., Enjuanes, A., Forcada, P., Muntanola, A., Hartmann, E. M., Calasanz, M. J., Rosenwald, A., Ott, G., Hernandez-Rivas, J. M., Klapper, W., Siebert, R., Wiestner, A., Wilson, W. H., Colomer, D., Lopez-Guillermo, A., Lopez-Otin, C., Puente, X. S. and Campo, E. Landscape of somatic mutations and clonal evolution in mantle cell lymphoma. Proc Natl Acad Sci U S A11018250-5 (2013).  PubMed
Fanjul-Fernandez, M., Quesada, V., Cabanillas, R., Cadinanos, J., Fontanil, T., Obaya, A., Ramsay, A. J., Llorente, J. L., Astudillo, A., Cal, S. and Lopez-Otin, C. Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas. Nature Commun42531 (2013).  PubMed
Martinez-Trillos, A., Quesada, V., Villamor, N., Puente, X. S., Lopez-Otin, C. and Campo, E. Recurrent gene mutations in CLL. Adv Exp Med Biol79287-107 (2013).  PubMed
Rivera-Torres, J., Acin-Perez, R., Cabezas-Sanchez, P., Osorio, F. G., Gonzalez-Gomez, C., Megias, D., Camara, C., Lopez-Otin, C., Enriquez, J. A., Luque-Garcia, J. L. and Andres, V. Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture. J Proteomics91466-77 (2013).  PubMed
Alexandrov, L. B., et al. Signatures of mutational processes in human cancer. Nature500415-21 (2013).  PubMed
de la Rosa, J., Freije, J. M., Cabanillas, R., Osorio, F. G., Fraga, M. F., Fernandez-Garcia, M. S., Rad, R., Fanjul, V., Ugalde, A. P., Liang, Q., Prosser, H. M., Bradley, A., Cadinanos, J. and Lopez-Otin, C. Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion. Nature Commun42268 (2013).  PubMed
Lapuente-Brun, E., Moreno-Loshuertos, R., Acin-Perez, R., Latorre-Pellicer, A., Colas, C., Balsa, E., Perales-Clemente, E., Quiros, P. M., Calvo, E., Rodriguez-Hernandez, M. A., Navas, P., Cruz, R., Carracedo, A., Lopez-Otin, C., Perez-Martos, A., Fernandez-Silva, P., Fernandez-Vizarra, E. and Enriquez, J. A. Supercomplex assembly determines electron flux in the mitochondrial electron transport chain. Science3401567-70 (2013).  PubMed
Cabrera, S., Fernandez, A. F., Marino, G., Aguirre, A., Suarez, M. F., Espanol, Y., Vega, J. A., Laura, R., Fueyo, A., Fernandez-Garcia, M. S., Freije, J. M., Kroemer, G. and Lopez-Otin, C. ATG4B/autophagin-1 regulates intestinal homeostasis and protects mice from experimental colitis. Autophagy91188-200 (2013).  PubMed
Berndt, S. I., et al. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Nature Genet45868-76 (2013).  PubMed
Lopez-Otin, C., Blasco, M. A., Partridge, L., Serrano, M. and Kroemer, G. The hallmarks of aging. Cell1531194-217 (2013).  PubMed
Lopez-Pelegrin, M., Cerda-Costa, N., Martinez-Jimenez, F., Cintas-Pedrola, A., Canals, A., Peinado, J. R., Marti-Renom, M. A., Lopez-Otin, C., Arolas, J. L. and Gomis-Ruth, F. X. A novel family of soluble minimal scaffolds provides structural insight into the catalytic domains of integral membrane metallopeptidases. J Biol Chem28821279-94 (2013).  PubMed
Vandenbroucke, R. E., Dejonckheere, E., Van Hauwermeiren, F., Lodens, S., De Rycke, R., Van Wonterghem, E., Staes, A., Gevaert, K., Lopez-Otin, C. and Libert, C. Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF. EMBO Mol Med5932-48 (2013).  PubMed
Martin-Subero, J. I., Lopez-Otin, C. and Campo, E. Genetic and epigenetic basis of chronic lymphocytic leukemia. Curr Opin Hematol20362-8 (2013).  PubMed
Quiros, P. M., Ramsay, A. J. and Lopez-Otin, C. New roles for OMA1 metalloprotease: From mitochondrial proteostasis to metabolic homeostasis. Adipocyte27-11 (2013).  PubMed
Villa-Bellosta, R., Rivera-Torres, J., Osorio, F. G., Acin-Perez, R., Enriquez, J. A., Lopez-Otin, C. and Andres, V. Defective extracellular pyrophosphate metabolism promotes vascular calcification in a mouse model of Hutchinson-Gilford progeria syndrome that is ameliorated on pyrophosphate treatment. Circulation1272442-51 (2013).  PubMed
Quesada, V., Ramsay, A. J., Rodriguez, D., Puente, X. S., Campo, E. and Lopez-Otin, C. The genomic landscape of chronic lymphocytic leukemia: clinical implications. BMC Med11124 (2013).  PubMed
Bassaganyas, L., Bea, S., Escaramis, G., Tornador, C., Salaverria, I., Zapata, L., Drechsel, O., Ferreira, P. G., Rodriguez-Santiago, B., Tubio, J. M., Navarro, A., Martin-Garcia, D., Lopez, C., Martinez-Trillos, A., Lopez-Guillermo, A., Gut, M., Ossowski, S., Lopez-Otin, C., Campo, E. and Estivill, X. Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by longitudinal genomic analysis. Leukemia272376-9 (2013).  PubMed
Fanjul-Fernandez, M., Folgueras, A. R., Fueyo, A., Balbin, M., Suarez, M. F., Fernandez-Garcia, M. S., Shapiro, S. D., Freije, J. M. and Lopez-Otin, C. Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses. J Biol Chem28814647-56 (2013).  PubMed
Ramsay, A. J., Quesada, V., Foronda, M., Conde, L., Martinez-Trillos, A., Villamor, N., Rodriguez, D., Kwarciak, A., Garabaya, C., Gallardo, M., Lopez-Guerra, M., Lopez-Guillermo, A., Puente, X. S., Blasco, M. A., Campo, E. and Lopez-Otin, C. POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia. Nature Genet45526-30 (2013).  PubMed
Puente, X. S. and Lopez-Otin, C. The evolutionary biography of chronic lymphocytic leukemia. Nature Genet45229-31 (2013).  PubMed
Rodriguez, D., Ramsay, A. J., Quesada, V., Garabaya, C., Campo, E., Freije, J. M. and Lopez-Otin, C. Functional analysis of sucrase-isomaltase mutations from chronic lymphocytic leukemia patients. Hum Mol Genet222273-82 (2013).  PubMed
Villamor, N., Conde, L., Martinez-Trillos, A., Cazorla, M., Navarro, A., Bea, S., Lopez, C., Colomer, D., Pinyol, M., Aymerich, M., Rozman, M., Abrisqueta, P., Baumann, T., Delgado, J., Gine, E., Gonzalez-Diaz, M., Hernandez, J. M., Colado, E., Payer, A. R., Rayon, C., Navarro, B., Jose Terol, M., Bosch, F., Quesada, V., Puente, X. S., Lopez-Otin, C., Jares, P., Pereira, A., Campo, E. and Lopez-Guillermo, A. NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome. Leukemia271100-6 (2013).  PubMed
Ramsay, A. J., Rodriguez, D., Villamor, N., Kwarciak, A., Tejedor, J. R., Valcarcel, J., Lopez-Guillermo, A., Martinez-Trillos, A., Puente, X. S., Campo, E., Lopez-Otin, C. and Quesada, V. Frequent somatic mutations in components of the RNA processing machinery in chronic lymphocytic leukemia. Leukemia271600-3 (2013).  PubMed
Diamandis, E. P., Bast RC, J. r. and Lopez-Otin, C. Conquering cancer in our lifetime: new diagnostic and therapeutic trends. Clin Chem591-3 (2013).  PubMed
Urdinguio, R. G., Fernandez, A. F., Moncada-Pazos, A., Huidobro, C., Rodriguez, R. M., Ferrero, C., Martinez-Camblor, P., Obaya, A. J., Bernal, T., Parra-Blanco, A., Rodrigo, L., Santacana, M., Matias-Guiu, X., Soldevilla, B., Dominguez, G., Bonilla, F., Cal, S., Lopez-Otin, C. and Fraga, M. F. Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors. Cancer Res73395-405 (2013).  PubMed
Ramsay, A. J., Martinez-Trillos, A., Jares, P., Rodriguez, D., Kwarciak, A. and Quesada, V. Next-generation sequencing reveals the secrets of the chronic lymphocytic leukemia genome. Clin Transl Oncol153-8 (2013).  PubMed
Blay, P., Santamaria, I., Pitiot, A. S., Luque, M., Alvarado, M. G., Lastra, A., Fernandez, Y., Paredes, A., Freije, J. M. and Balbin, M. Mutational analysis of BRCA1 and BRCA2 in hereditary breast and ovarian cancer families from Asturias (Northern Spain). BMC Cancer13243 (2013).  PubMed
Barcena, C., Osorio, F. G. and Freije, J. M. Detection of nuclear envelope alterations in senescence. Methods Mol Biol965243-51 (2013).  PubMed
Osorio, F. G., de la Rosa, J. and Freije, J. M. Luminescence-based in vivo monitoring of NF-kappaB activity through a gene delivery approach. Cell Commun Signal1119 (2013).  PubMed

2012

Valdes-Mas, R., Bea, S., Puente, D. A., Lopez-Otin, C. and Puente, X. S. Estimation of copy number alterations from exome sequencing data. PLoS One7e51422 (2012).  PubMed
Aikio, M., Alahuhta, I., Nurmenniemi, S., Suojanen, J., Palovuori, R., Teppo, S., Sorsa, T., Lopez-Otin, C., Pihlajaniemi, T., Salo, T., Heljasvaara, R. and Nyberg, P. Arresten, a collagen-derived angiogenesis inhibitor, suppresses invasion of squamous cell carcinoma. PLoS One7e51044 (2012).  PubMed
Osorio, F. G., Lopez-Otin, C. and Freije, J. M. NF-kB in premature aging. Aging (Albany NY)4726-7 (2012).  PubMed
Yu, G., Kovkarova-Naumovski, E., Jara, P., Parwani, A., Kass, D., Ruiz, V., Lopez-Otin, C., Rosas, I. O., Gibson, K. F., Cabrera, S., Ramirez, R., Yousem, S. A., Richards, T. J., Chensny, L. J., Selman, M., Kaminski, N. and Pardo, A. Matrix metalloproteinase-19 is a key regulator of lung fibrosis in mice and humans. Am J Respir Crit Care Med186752-62 (2012).  PubMed
Osorio, F. G., Barcena, C., Soria-Valles, C., Ramsay, A. J., de Carlos, F., Cobo, J., Fueyo, A., Freije, J. M. and Lopez-Otin, C. Nuclear lamina defects cause ATM-dependent NF-kappaB activation and link accelerated aging to a systemic inflammatory response. Genes Dev262311-24 (2012).  PubMed
Paulissen, G., El Hour, M., Rocks, N., Gueders, M. M., Bureau, F., Foidart, J. M., Lopez-Otin, C., Noel, A. and Cataldo, D. D. Control of allergen-induced inflammation and hyperresponsiveness by the metalloproteinase ADAMTS-12. J Immunol1894135-43 (2012).  PubMed
Kulis, M., Heath, S., Bibikova, M., Queiros, A. C., Navarro, A., Clot, G., Martinez-Trillos, A., Castellano, G., Brun-Heath, I., Pinyol, M., Barberan-Soler, S., Papasaikas, P., Jares, P., Bea, S., Rico, D., Ecker, S., Rubio, M., Royo, R., Ho, V., Klotzle, B., Hernandez, L., Conde, L., Lopez-Guerra, M., Colomer, D., Villamor, N., Aymerich, M., Rozman, M., Bayes, M., Gut, M., Gelpi, J. L., Orozco, M., Fan, J. B., Quesada, V., Puente, X. S., Pisano, D. G., Valencia, A., Lopez-Guillermo, A., Gut, I., Lopez-Otin, C., Campo, E. and Martin-Subero, J. I. Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia. Nature Genet441236-42 (2012).  PubMed
Kuang, E., Okumura, C. Y., Sheffy-Levin, S., Varsano, T., Shu, V. C., Qi, J., Niesman, I. R., Yang, H. J., Lopez-Otin, C., Yang, W. Y., Reed, J. C., Broday, L., Nizet, V. and Ronai, Z. A. Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection. PLoS Genet8e1003007 (2012).  PubMed
Senovilla, L., Vitale, I., Martins, I., Tailler, M., Pailleret, C., Michaud, M., Galluzzi, L., Adjemian, S., Kepp, O., Niso-Santano, M., Shen, S., Marino, G., Criollo, A., Boileve, A., Job, B., Ladoire, S., Ghiringhelli, F., Sistigu, A., Yamazaki, T., Rello-Varona, S., Locher, C., Poirier-Colame, V., Talbot, M., Valent, A., Berardinelli, F., Antoccia, A., Ciccosanti, F., Fimia, G. M., Piacentini, M., Fueyo, A., Messina, N. L., Li, M., Chan, C. J., Sigl, V., Pourcher, G., Ruckenstuhl, C., Carmona-Gutierrez, D., Lazar, V., Penninger, J. M., Madeo, F., Lopez-Otin, C., Smyth, M. J., Zitvogel, L., Castedo, M. and Kroemer, G. An immunosurveillance mechanism controls cancer cell ploidy. Science3371678-84 (2012).  PubMed
Moncada-Pazos, A., Obaya, A. J., Llamazares, M., Heljasvaara, R., Suarez, M. F., Colado, E., Noel, A., Cal, S. and Lopez-Otin, C. ADAMTS-12 metalloprotease is necessary for normal inflammatory response. J Biol Chem28739554-63 (2012).  PubMed
Freije, J. M. and Lopez-Otin, C. Reprogramming aging and progeria. Curr Opin Cell Biol24757-64 (2012).  PubMed
Vandenbroucke, R. E., Dejonckheere, E., Van Lint, P., Demeestere, D., Van Wonterghem, E., Vanlaere, I., Puimege, L., Van Hauwermeiren, F., De Rycke, R., Mc Guire, C., Campestre, C., Lopez-Otin, C., Matthys, P., Leclercq, G. and Libert, C. Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases. J Neurosci329805-16 (2012).  PubMed
Quesada, V., Ramsay, A. J. and Lopez-Otin, C. Chronic lymphocytic leukemia with SF3B1 mutation. N Engl J Med3662530 (2012).  PubMed
Fraile, J. M., Quesada, V., Rodriguez, D., Freije, J. M. and Lopez-Otin, C. Deubiquitinases in cancer: new functions and therapeutic options. Oncogene312373-88 (2012).  PubMed
Hwang, S., Maloney, N. S., Bruinsma, M. W., Goel, G., Duan, E., Zhang, L., Shrestha, B., Diamond, M. S., Dani, A., Sosnovtsev, S. V., Green, K. Y., Lopez-Otin, C., Xavier, R. J., Thackray, L. B. and Virgin, H. W. Nondegradative role of Atg5-Atg12/ Atg16L1 autophagy protein complex in antiviral activity of interferon gamma. Cell Host Microbe11397-409 (2012).  PubMed
Klionsky, D. J., et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy8445-544 (2012).  PubMed
Quiros, P. M., Ramsay, A. J., Sala, D., Fernandez-Vizarra, E., Rodriguez, F., Peinado, J. R., Fernandez-Garcia, M. S., Vega, J. A., Enriquez, J. A., Zorzano, A. and Lopez-Otin, C. Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice. EMBO J312117-33 (2012).  PubMed
Vazquez-Martin, A., Vellon, L., Quiros, P. M., Cufi, S., Ruiz de Galarreta, E., Oliveras-Ferraros, C., Martin, A. G., Martin-Castillo, B., Lopez-Otin, C. and Menendez, J. A. Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells. Cell Cycle11974-89 (2012).  PubMed
Starr, T., Child, R., Wehrly, T. D., Hansen, B., Hwang, S., Lopez-Otin, C., Virgin, H. W. and Celli, J. Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle. Cell Host Microbe1133-45 (2012).  PubMed
Noel, A., Gutierrez-Fernandez, A., Sounni, N. E., Behrendt, N., Maquoi, E., Lund, I. K., Cal, S., Hoyer-Hansen, G. and Lopez-Otin, C. New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment. Front Pharmacol3140 (2012).  PubMed
Quesada, V., et al. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nature Genet4447-52 (2012).  PubMed

2011

Osorio, F. G., Ugalde, A. P., Marino, G., Puente, X. S., Freije, J. M. and Lopez-Otin, C. Cell autonomous and systemic factors in progeria development. Biochem Soc Trans391710-4 (2011).  PubMed
Ugalde, A. P., Espanol, Y. and Lopez-Otin, C. Micromanaging aging with miRNAs: new messages from the nuclear envelope. Nucleus2549-55 (2011).  PubMed
Cabanillas, R., Cadinanos, J., Villameytide, J. A., Perez, M., Longo, J., Richard, J. M., Alvarez, R., Duran, N. S., Illan, R., Gonzalez, D. J. and Lopez-Otin, C. Nestor-Guillermo progeria syndrome: a novel premature aging condition with early onset and chronic development caused by BANF1 mutations. Am J Med Genet A155A2617-25 (2011).  PubMed
Osorio, F. G., Navarro, C. L., Cadinanos, J., Lopez-Mejia, I. C., Quiros, P. M., Bartoli, C., Rivera, J., Tazi, J., Guzman, G., Varela, I., Depetris, D., de Carlos, F., Cobo, J., Andres, V., De Sandre-Giovannoli, A., Freije, J. M., Levy, N. and Lopez-Otin, C. Splicing-directed therapy in a new mouse model of human accelerated aging. Sci Transl Med3106ra107 (2011).  PubMed
Lopez-Mejia, I. C., Vautrot, V., De Toledo, M., Behm-Ansmant, I., Bourgeois, C. F., Navarro, C. L., Osorio, F. G., Freije, J. M., Stevenin, J., De Sandre-Giovannoli, A., Lopez-Otin, C., Levy, N., Branlant, C. and Tazi, J. A conserved splicing mechanism of the LMNA gene controls premature aging. Hum Mol Genet204540-55 (2011).  PubMed
Peinado, J. R., Quiros, P. M., Pulido, M. R., Marino, G., Martinez-Chantar, M. L., Vazquez-Martinez, R., Freije, J. M., Lopez-Otin, C. and Malagon, M. M. Proteomic profiling of adipose tissue from Zmpste24-/- mice, a model of lipodystrophy and premature aging, reveals major changes in mitochondrial function and vimentin processing. Mol Cell Proteomics10M111.008094 (2011).  PubMed
NISC Comparative Sequencing Program. Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. Hum Mutat32E2148-75 (2011).  PubMed
Puente, X. S., et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature475101-5 (2011).  PubMed
Meynard, D., Vaja, V., Sun, C. C., Corradini, E., Chen, S., Lopez-Otin, C., Grgurevic, L., Hong, C. C., Stirnberg, M., Gutschow, M., Vukicevic, S., Babitt, J. L. and Lin, H. Y. Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. Blood118747-56 (2011).  PubMed
Ugalde, A. P., Ramsay, A. J., de la Rosa, J., Varela, I., Marino, G., Cadinanos, J., Lu, J., Freije, J. M. and Lopez-Otin, C. Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53. EMBO J302219-32 (2011).  PubMed
Puente, X. S., Quesada, V., Osorio, F. G., Cabanillas, R., Cadinanos, J., Fraile, J. M., Ordonez, G. R., Puente, D. A., Gutierrez-Fernandez, A., Fanjul-Fernandez, M., Levy, N., Freije, J. M. and Lopez-Otin, C. Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome. Am J Hum Genet88650-6 (2011).  PubMed
Moncada-Pazos, A., Obaya, A. J., Viloria, C. G., Lopez-Otin, C. and Cal, S. The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities. J Mol Med (Berl)89611-9 (2011).  PubMed
Marino, G., Morselli, E., Bennetzen, M. V., Eisenberg, T., Megalou, E., Schroeder, S., Cabrera, S., Benit, P., Rustin, P., Criollo, A., Kepp, O., Galluzzi, L., Shen, S., Malik, S. A., Maiuri, M. C., Horio, Y., Lopez-Otin, C., Andersen, J. S., Tavernarakis, N., Madeo, F. and Kroemer, G. Longevity-relevant regulation of autophagy at the level of the acetylproteome. Autophagy7647-9 (2011).  PubMed
Morselli, E., Marino, G., Bennetzen, M. V., Eisenberg, T., Megalou, E., Schroeder, S., Cabrera, S., Benit, P., Rustin, P., Criollo, A., Kepp, O., Galluzzi, L., Shen, S., Malik, S. A., Maiuri, M. C., Horio, Y., Lopez-Otin, C., Andersen, J. S., Tavernarakis, N., Madeo, F. and Kroemer, G. Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol192615-29 (2011).  PubMed
Locke, D. P., et al. Comparative and demographic analysis of orang-utan genomes. Nature469529-33 (2011).  PubMed
Lenoir, A., Deschemin, J. C., Kautz, L., Ramsay, A. J., Roth, M. P., Lopez-Otin, C., Vaulont, S. and Nicolas, G. Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6. Blood117647-50 (2011).  PubMed
Freije, J. M., Fraile, J. M. and Lopez-Otin, C. Protease addiction and synthetic lethality in cancer. Front Oncol125 (2011).  PubMed

2010

Ugalde, A. P., Marino, G. and Lopez-Otin, C. Rejuvenating somatotropic signaling: a therapeutical opportunity for premature aging? Aging (Albany NY)21017-22 (2010).  PubMed
Garcia, S., Forteza, J., Lopez-Otin, C., Gomez-Reino, J. J., Gonzalez, A. and Conde, C. Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model. Arthritis Res Ther12R224 (2010).  PubMed
NISC Comparative Sequencing Program. Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma. Mol Cancer Res81513-25 (2010).  PubMed
Maloberti, P. M., Duarte, A. B., Orlando, U. D., Pasqualini, M. E., Solano, A. R., Lopez-Otin, C. and Podesta, E. J. Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells. PLoS One5e15540 (2010).  PubMed
Osorio, F. G., Varela, I., Lara, E., Puente, X. S., Espada, J., Santoro, R., Freije, J. M., Fraga, M. F. and Lopez-Otin, C. Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease. Aging Cell9947-57 (2010).  PubMed
Albaiceta, G. M., Gutierrez-Fernandez, A., Garcia-Prieto, E., Puente, X. S., Parra, D., Astudillo, A., Campestre, C., Cabrera, S., Gonzalez-Lopez, A., Fueyo, A., Taboada, F. and Lopez-Otin, C. Absence or inhibition of matrix metalloproteinase-8 decreases ventilator-induced lung injury. Am J Respir Cell Mol Biol43555-63 (2010).  PubMed
Garcia-Prieto, E., Gonzalez-Lopez, A., Cabrera, S., Astudillo, A., Gutierrez-Fernandez, A., Fanjul-Fernandez, M., Batalla-Solis, E., Puente, X. S., Fueyo, A., Lopez-Otin, C. and Albaiceta, G. M. Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10. PLoS One5e13242 (2010).  PubMed
Cabrera, S., Marino, G., Fernandez, A. F. and Lopez-Otin, C. Autophagy, proteases and the sense of balance. Autophagy6961-3 (2010).  PubMed
Marino, G., Ugalde, A. P., Fernandez, A. F., Osorio, F. G., Fueyo, A., Freije, J. M. and Lopez-Otin, C. Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function. Proc Natl Acad Sci U S A10716268-73 (2010).  PubMed
Diamandis, E. P., Hudson, T., Kallioniemi, O., Liu, E. T. and Lopez-Otin, C. Cancer genomes. Clin Chem561660-4 (2010).  PubMed
Gueders, M. M., Hirst, S. J., Quesada-Calvo, F., Paulissen, G., Hacha, J., Gilles, C., Gosset, P., Louis, R., Foidart, J. M., Lopez-Otin, C., Noel, A. and Cataldo, D. D. Matrix metalloproteinase-19 deficiency promotes tenascin-C accumulation and allergen-induced airway inflammation. Am J Respir Cell Mol Biol43286-95 (2010).  PubMed
Marino, G., Fernandez, A. F., Cabrera, S., Lundberg, Y. W., Cabanillas, R., Rodriguez, F., Salvador-Montoliu, N., Vega, J. A., Germana, A., Fueyo, A., Freije, J. M. and Lopez-Otin, C. Autophagy is essential for mouse sense of balance. J Clin Invest1202331-44 (2010).  PubMed
Lara, E., Calvanese, V., Huidobro, C., Fernandez, A. F., Moncada-Pazos, A., Obaya, A. J., Aguilera, O., Gonzalez-Sancho, J. M., Sanchez, L., Astudillo, A., Munoz, A., Lopez-Otin, C., Esteller, M. and Fraga, M. F. Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer. Mol Cancer9170 (2010).  PubMed
El Hour, M., Moncada-Pazos, A., Blacher, S., Masset, A., Cal, S., Berndt, S., Detilleux, J., Host, L., Obaya, A. J., Maillard, C., Foidart, J. M., Ectors, F., Noel, A. and Lopez-Otin, C. Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis. Oncogene293025-32 (2010).  PubMed
International Cancer Genome Consortium. International network of cancer genome projects. Nature464993-8 (2010).  PubMed
Quesada, V., Velasco, G., Puente, X. S., Warren, W. C. and Lopez-Otin, C. Comparative genomic analysis of the zebra finch degradome provides new insights into evolution of proteases in birds and mammals. BMC Genomics11220 (2010).  PubMed
Lopez-Otin, C. and Hunter, T. The regulatory crosstalk between kinases and proteases in cancer. Nature Rev Cancer10278-92 (2010).  PubMed
Warren, W. C., et al. The genome of a songbird. Nature464757-62 (2010).  PubMed
Marino, G., Fernandez, A. F. and Lopez-Otin, C. Autophagy and aging: lessons from progeria models. Adv Exp Med Biol69461-8 (2010).  PubMed
Fanjul-Fernandez, M., Folgueras, A. R., Cabrera, S. and Lopez-Otin, C. Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models. Biochim Biophys Acta18033-19 (2010).  PubMed
Alvarez-Diaz, S., Larriba, M. J., Lopez-Otin, C. and Munoz, A. Vitamin D: Proteases, protease inhibitors and cancer. Cell Cycle932-7 (2010).  PubMed
Ugalde, A. P., Ordonez, G. R., Quiros, P. M., Puente, X. S. and Lopez-Otin, C. Metalloproteases and the degradome. Methods Mol Biol6223-29 (2010).  PubMed

2009

Gueders, M. M., Hirst, S. J., Quesada-Calvo, F., Paulissen, G., Hacha, J., Gilles, C., Gosset, P., Louis, R., Foidart, J. M., Lopez-Otin, C., Noel, A. and Cataldo, D. D. Matrix metalloproteinase-19 deficiency promotes tenascin-C accumulation and allergen-induced airway inflammation. Am J Respir Cell Mol Biol43286-95 (2010).  PubMed
Osorio, F. G., Obaya, A. J., Lopez-Otin, C. and Freije, J. M. Accelerated ageing: from mechanism to therapy through animal models. Transgenic Res187-15 (2009).  PubMed
Quesada, V., Ordonez, G. R., Sanchez, L. M., Puente, X. S. and Lopez-Otin, C. The Degradome database: mammalian proteases and diseases of proteolysis. Nucleic Acids Res37D239-43 (2009).  PubMed
Ramsay, A. J., Hooper, J. D., Folgueras, A. R., Velasco, G. and Lopez-Otin, C. Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis. Haematologica94840-9 (2009).  PubMed
Viloria, C. G., Obaya, A. J., Moncada-Pazos, A., Llamazares, M., Astudillo, A., Capella, G., Cal, S. and Lopez-Otin, C. Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer. Cancer Res694926-34 (2009).  PubMed
Moncada-Pazos, A., Obaya, A. J., Fraga, M. F., Viloria, C. G., Capella, G., Gausachs, M., Esteller, M., Lopez-Otin, C. and Cal, S. The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer. J Cell Sci1222906-13 (2009).  PubMed
Alvarez-Diaz, S., Valle, N., Garcia, J. M., Pena, C., Freije, J. M., Quesada, V., Astudillo, A., Bonilla, F., Lopez-Otin, C. and Munoz, A. Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells. J Clin Invest1192343-58 (2009).  PubMed
Ramsay, A. J., Quesada, V., Sanchez, M., Garabaya, C., Sarda, M. P., Baiget, M., Remacha, A., Velasco, G. and Lopez-Otin, C. Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms. Hum Mol Genet183673-83 (2009).  PubMed
Folgueras, A. R., Valdes-Sanchez, T., Llano, E., Menendez, L., Baamonde, A., Denlinger, B. L., Belmonte, C., Juarez, L., Lastra, A., Garcia-Suarez, O., Astudillo, A., Kirstein, M., Pendas, A. M., Farinas, I. and Lopez-Otin, C. Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation. Proc Natl Acad Sci U S A10616451-6 (2009).  PubMed
Laxton, R. C., Hu, Y., Duchene, J., Zhang, F., Zhang, Z., Leung, K. Y., Xiao, Q., Scotland, R. S., Hodgkinson, C. P., Smith, K., Willeit, J., Lopez-Otin, C., Simpson, I. A., Kiechl, S., Ahluwalia, A., Xu, Q. and Ye, S. A role of matrix metalloproteinase-8 in atherosclerosis. Circ Res105921-9 (2009).  PubMed
Lopez-Otin, C., Palavalli, L. H. and Samuels, Y. Protective roles of matrix metalloproteinases: from mouse models to human cancer. Cell Cycle83657-62 (2009).  PubMed
Ordonez, G. R., Puente, X. S., Quesada, V. and Lopez-Otin, C. Proteolytic systems: constructing degradomes. Methods Mol Biol53933-47 (2009).  PubMed

2008

Varela, I., Pereira, S., Ugalde, A. P., Navarro, C. L., Suarez, M. F., Cau, P., Cadinanos, J., Osorio, F. G., Foray, N., Cobo, J., de Carlos, F., Levy, N., Freije, J. M. and Lopez-Otin, C. Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging. Nature Med14767-72 (2008).  PubMed
Warren, W. C., et al. Genome analysis of the platypus reveals unique signatures of evolution. Nature453175-83 (2008).  PubMed
Ordonez, G. R., Hillier, L. W., Warren, W. C., Grutzner, F., Lopez-Otin, C. and Puente, X. S. Loss of genes implicated in gastric function during platypus evolution. Genome Biol9R81 (2008).  PubMed
Marino, G., Ugalde, A. P., Salvador-Montoliu, N., Varela, I., Quiros, P. M., Cadinanos, J., van der Pluijm, I., Freije, J. M. and Lopez-Otin, C. Premature aging in mice activates a systemic metabolic response involving autophagy induction. Hum Mol Genet172196-211 (2008).  PubMed
Marino, G. and Lopez-Otin, C. Autophagy and aging: new lessons from progeroid mice. Autophagy4807-9 (2008).  PubMed
Lopez-Otin, C. and Bond, J. S. Proteases: multifunctional enzymes in life and disease. J Biol Chem28330433-7 (2008).  PubMed
Lizarbe, T. R., Garcia-Rama, C., Tarin, C., Saura, M., Calvo, E., Lopez, J. A., Lopez-Otin, C., Folgueras, A. R., Lamas, S. and Zaragoza, C. Nitric oxide elicits functional MMP-13 protein-tyrosine nitration during wound repair. FASEB J223207-15 (2008).  PubMed
Korpi, J. T., Kervinen, V., Maklin, H., Vaananen, A., Lahtinen, M., Laara, E., Ristimaki, A., Thomas, G., Ylipalosaari, M., Astrom, P., Lopez-Otin, C., Sorsa, T., Kantola, S., Pirila, E. and Salo, T. Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer. Br J Cancer98766-75 (2008).  PubMed
Gutierrez-Fernandez, A., Fueyo, A., Folgueras, A. R., Garabaya, C., Pennington, C. J., Pilgrim, S., Edwards, D. R., Holliday, D. L., Jones, J. L., Span, P. N., Sweep, F. C., Puente, X. S. and Lopez-Otin, C. Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion. Cancer Res682755-63 (2008).  PubMed
Folgueras, A. R., Fueyo, A., Garcia-Suarez, O., Cox, J., Astudillo, A., Tortorella, P., Campestre, C., Gutierrez-Fernandez, A., Fanjul-Fernandez, M., Pennington, C. J., Edwards, D. R., Overall, C. M. and Lopez-Otin, C. Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice. J Biol Chem2839465-74 (2008).  PubMed
Folgueras, A. R., de Lara, F. M., Pendas, A. M., Garabaya, C., Rodriguez, F., Astudillo, A., Bernal, T., Cabanillas, R., Lopez-Otin, C. and Velasco, G. Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis. Blood1122539-45 (2008).  PubMed
Espada, J., Varela, I., Flores, I., Ugalde, A. P., Cadinanos, J., Pendas, A. M., Stewart, C. L., Tryggvason, K., Blasco, M. A., Freije, J. M. and Lopez-Otin, C. Nuclear envelope defects cause stem cell dysfunction in premature-aging mice. J Cell Biol18127-35 (2008).  PubMed

2007

Van Roy, M., Van Lint, P., Van Laere, I., Wielockx, B., Wilson, C., Lopez-Otin, C., Shapiro, S. and Libert, C. Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNgamma-based cancer therapy in mice. Mol Cancer Ther62563-71 (2007).  PubMed
Tester, A. M., Cox, J. H., Connor, A. R., Starr, A. E., Dean, R. A., Puente, X. S., Lopez-Otin, C. and Overall, C. M. LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity. PLoS One2e312 (2007).  PubMed
Ramirez, C. L., Cadinanos, J., Varela, I., Freije, J. M. and Lopez-Otin, C. Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions. Cell Mol Life Sci64155-70 (2007).  PubMed
Pirila, E., Korpi, J. T., Korkiamaki, T., Jahkola, T., Gutierrez-Fernandez, A., Lopez-Otin, C., Saarialho-Kere, U., Salo, T. and Sorsa, T. Collagenase-2 (MMP-8) and matrilysin-2 (MMP-26) expression in human wounds of different etiologies. Wound Repair Regen1547-57 (2007).  PubMed
Marino, G., Salvador-Montoliu, N., Fueyo, A., Knecht, E., Mizushima, N. and Lopez-Otin, C. Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem28218573-83 (2007).  PubMed
Lopez-Otin, C. and Matrisian, L. M. Emerging roles of proteases in tumour suppression. Nature Rev Cancer7800-8 (2007).  PubMed
Llamazares, M., Obaya, A. J., Moncada-Pazos, A., Heljasvaara, R., Espada, J., Lopez-Otin, C. and Cal, S. The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway. J Cell Sci1203544-52 (2007).  PubMed
Gutierrez-Fernandez, A., Inada, M., Balbin, M., Fueyo, A., Pitiot, A. S., Astudillo, A., Hirose, K., Hirata, M., Shapiro, S. D., Noel, A., Werb, Z., Krane, S. M., Lopez-Otin, C. and Puente, X. S. Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). FASEB J212580-91 (2007).  PubMed
Cal, S., Moncada-Pazos, A. and Lopez-Otin, C. Expanding the complexity of the human degradome: polyserases and their tandem serine protease domains. Front Biosci124661-9 (2007).  PubMed

2006

Puente, X. S., Velasco, G., Gutierrez-Fernandez, A., Bertranpetit, J., King, M. C. and Lopez-Otin, C. Comparative analysis of cancer genes in the human and chimpanzee genomes. BMC Genomics715 (2006).  PubMed
Jost, M., Folgueras, A. R., Frerart, F., Pendas, A. M., Blacher, S., Houard, X., Berndt, S., Munaut, C., Cataldo, D., Alvarez, J., Melen-Lamalle, L., Foidart, J. M., Lopez-Otin, C. and Noel, A. Earlier onset of tumoral angiogenesis in matrix metalloproteinase-19-deficient mice. Cancer Res665234-41 (2006).  PubMed
Hernandez, M., Valenzuela, M. A., Lopez-Otin, C., Alvarez, J., Lopez, J. M., Vernal, R. and Gamonal, J. Matrix metalloproteinase-13 is highly expressed in destructive periodontal disease activity. J Periodontol771863-70 (2006).  PubMed
Gonzalez, L., Freije, J. M., Cal, S., Lopez-Otin, C., Serrano, M. and Palmero, I. A functional link between the tumour suppressors ARF and p33ING1. Oncogene255173-9 (2006).  PubMed
Chabottaux, V., Sounni, N. E., Pennington, C. J., English, W. R., van den Brule, F., Blacher, S., Gilles, C., Munaut, C., Maquoi, E., Lopez-Otin, C., Murphy, G., Edwards, D. R., Foidart, J. M. and Noel, A. Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases. Cancer Res665165-72 (2006).  PubMed
Cal, S., Peinado, J. R., Llamazares, M., Quesada, V., Moncada-Pazos, A., Garabaya, C. and Lopez-Otin, C. Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain. BMC Biochem79 (2006).  PubMed

2005

Wang, X., Inoue, S., Gu, J., Miyoshi, E., Noda, K., Li, W., Mizuno-Horikawa, Y., Nakano, M., Asahi, M., Takahashi, M., Uozumi, N., Ihara, S., Lee, S. H., Ikeda, Y., Yamaguchi, Y., Aze, Y., Tomiyama, Y., Fujii, J., Suzuki, K., Kondo, A., Shapiro, S. D., Lopez-Otin, C., Kuwaki, T., Okabe, M., Honke, K. and Taniguchi, N. Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. Proc Natl Acad Sci U S A10215791-6 (2005).  PubMed
Varela, I., Cadinanos, J., Pendas, A. M., Gutierrez-Fernandez, A., Folgueras, A. R., Sanchez, L. M., Zhou, Z., Rodriguez, F. J., Stewart, C. L., Vega, J. A., Tryggvason, K., Freije, J. M. and Lopez-Otin, C. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature437564-8 (2005).  PubMed
Van Lint, P., Wielockx, B., Puimege, L., Noel, A., Lopez-Otin, C. and Libert, C. Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis. J Immunol1757642-9 (2005).  PubMed
Tao, Z., Peng, Y., Nolasco, L., Cal, S., Lopez-Otin, C., Li, R., Moake, J. L., Lopez, J. A. and Dong, J. F. Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions. Blood1064139-45 (2005).  PubMed
Puente, X. S., Sanchez, L. M., Gutierrez-Fernandez, A., Velasco, G. and Lopez-Otin, C. A genomic view of the complexity of mammalian proteolytic systems. Biochem Soc Trans33331-4 (2005).  PubMed
Puente, X. S., Gutierrez-Fernandez, A., Ordonez, G. R., Hillier, L. W. and Lopez-Otin, C. Comparative genomic analysis of human and chimpanzee proteases. Genomics86638-47 (2005).  PubMed
Navarro, C. L., Cadinanos, J., De Sandre-Giovannoli, A., Bernard, R., Courrier, S., Boccaccio, I., Boyer, A., Kleijer, W. J., Wagner, A., Giuliano, F., Beemer, F. A., Freije, J. M., Cau, P., Hennekam, R. C., Lopez-Otin, C., Badens, C. and Levy, N. Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors. Hum Mol Genet141503-13 (2005).  PubMed
Liu, B., Wang, J., Chan, K. M., Tjia, W. M., Deng, W., Guan, X., Huang, J. D., Li, K. M., Chau, P. Y., Chen, D. J., Pei, D., Pendas, A. M., Cadinanos, J., Lopez-Otin, C., Tse, H. F., Hutchison, C., Chen, J., Cao, Y., Cheah, K. S., Tryggvason, K. and Zhou, Z. Genomic instability in laminopathy-based premature aging. Nature Med11780-5 (2005).  PubMed
Levy, N., Lopez-Otin, C. and Hennekam, R. C. Defective prelamin A processing resulting from LMNA or ZMPSTE24 mutations as the cause of restrictive dermopathy. Arch Dermatol1411473-4; author reply 1474 (2005).  PubMed
Kennedy, A. M., Inada, M., Krane, S. M., Christie, P. T., Harding, B., Lopez-Otin, C., Sanchez, L. M., Pannett, A. A., Dearlove, A., Hartley, C., Byrne, M. H., Reed, A. A., Nesbit, M. A., Whyte, M. P. and Thakker, R. V. MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO). J Clin Invest1152832-42 (2005).  PubMed
Gueders, M. M., Balbin, M., Rocks, N., Foidart, J. M., Gosset, P., Louis, R., Shapiro, S., Lopez-Otin, C., Noel, A. and Cataldo, D. D. Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J Immunol1752589-97 (2005).  PubMed
Diaz-Perales, A., Quesada, V., Sanchez, L. M., Ugalde, A. P., Suarez, M. F., Fueyo, A. and Lopez-Otin, C. Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase. J Biol Chem28014310-7 (2005).  PubMed
Diaz-Perales, A., Quesada, V., Peinado, J. R., Ugalde, A. P., Alvarez, J., Suarez, M. F., Gomis-Ruth, F. X. and Lopez-Otin, C. Identification and characterization of human archaemetzincin-1 and -2, two novel members of a family of metalloproteases widely distributed in Archaea. J Biol Chem28030367-75 (2005).  PubMed
Chimpanzee Sequencing and Analysis Consortium. Initial sequence of the chimpanzee genome and comparison with the human genome. Nature43769-87 (2005).  PubMed
Cal, S., Quesada, V., Llamazares, M., Diaz-Perales, A., Garabaya, C. and Lopez-Otin, C. Human polyserase-2, a novel enzyme with three tandem serine protease domains in a single polypeptide chain. J Biol Chem2801953-61 (2005).  PubMed
Cadinanos, J., Varela, I., Lopez-Otin, C. and Freije, J. M. From immature lamin to premature aging: molecular pathways and therapeutic opportunities. Cell Cycle41732-5 (2005).  PubMed
Appenzeller-Herzog, C., Nyfeler, B., Burkhard, P., Santamaria, I., Lopez-Otin, C. and Hauri, H. P. Carbohydrate- and conformation-dependent cargo capture for ER-exit. Mol Biol Cell161258-67 (2005).  PubMed

2004

Sabeh, F., Ota, I., Holmbeck, K., Birkedal-Hansen, H., Soloway, P., Balbin, M., Lopez-Otin, C., Shapiro, S., Inada, M., Krane, S., Allen, E., Chung, D. and Weiss, S. J. Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP. J Cell Biol167769-81 (2004).  PubMed
Rat Genome Sequencing Project Consortium. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature428493-521 (2004).  PubMed
Rasmussen, F. H., Yeung, N., Kiefer, L., Murphy, G., Lopez-Otin, C., Vitek, M. P. and Moss, M. L. Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases. Biochemistry432987-95 (2004).  PubMed
Quesada, V., Diaz-Perales, A., Gutierrez-Fernandez, A., Garabaya, C., Cal, S. and Lopez-Otin, C. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Biochem Biophys Res Commun31454-62 (2004).  PubMed
Quesada, V., Sanchez, L. M., Alvarez, J. and Lopez-Otin, C. Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish. J Biol Chem27926627-34 (2004).  PubMed
Puente, X. S. and Lopez-Otin, C. A genomic analysis of rat proteases and protease inhibitors. Genome Res14609-22 (2004).  PubMed
Pendas, A. M., Folgueras, A. R., Llano, E., Caterina, J., Frerard, F., Rodriguez, F., Astudillo, A., Noel, A., Birkedal-Hansen, H. and Lopez-Otin, C. Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient mice. Mol Cell Biol245304-13 (2004).  PubMed
Owen, C. A., Hu, Z., Lopez-Otin, C. and Shapiro, S. D. Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase. J Immunol1727791-803 (2004).  PubMed
Overall, C. M., Tam, E. M., Kappelhoff, R., Connor, A., Ewart, T., Morrison, C. J., Puente, X., Lopez-Otin, C. and Seth, A. Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors. Biol Chem385493-504 (2004).  PubMed
Marino, G. and Lopez-Otin, C. Autophagy: molecular mechanisms, physiological functions and relevance in human pathology. Cell Mol Life Sci611439-54 (2004).  PubMed
Inada, M., Wang, Y., Byrne, M. H., Rahman, M. U., Miyaura, C., Lopez-Otin, C. and Krane, S. M. Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A10117192-7 (2004).  PubMed
Folgueras, A. R., Pendas, A. M., Sanchez, L. M. and Lopez-Otin, C. Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies. Int J Dev Biol48411-24 (2004).  PubMed
Bister, V. O., Salmela, M. T., Karjalainen-Lindsberg, M. L., Uria, J., Lohi, J., Puolakkainen, P., Lopez-Otin, C. and Saarialho-Kere, U. Differential expression of three matrix metalloproteinases, MMP-19, MMP-26, and MMP-28, in normal and inflamed intestine and colon cancer. Dig Dis Sci49653-61 (2004).  PubMed

2003

Zucker, S., Pei, D., Cao, J. and Lopez-Otin, C. Membrane type-matrix metalloproteinases (MT-MMP). Curr Top Dev Biol541-74 (2003).  PubMed
Puente, X. S., Sanchez, L. M., Overall, C. M. and Lopez-Otin, C. Human and mouse proteases: a comparative genomic approach. Nature Rev Genet4544-58 (2003).  PubMed
Marino, G., Uria, J. A., Puente, X. S., Quesada, V., Bordallo, J. and Lopez-Otin, C. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. J Biol Chem2783671-8 (2003).  PubMed
Llamazares, M., Cal, S., Quesada, V. and Lopez-Otin, C. Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain. J Biol Chem27813382-9 (2003).  PubMed
Hieta, N., Impola, U., Lopez-Otin, C., Saarialho-Kere, U. and Kahari, V. M. Matrix metalloproteinase-19 expression in dermal wounds and by fibroblasts in culture. J Invest Dermatol121997-1004 (2003).  PubMed
Freije, J. M., Balbin, M., Pendas, A. M., Sanchez, L. M., Puente, X. S. and Lopez-Otin, C. Matrix metalloproteinases and tumor progression. Adv Exp Med Biol53291-107 (2003).  PubMed
Cal, S., Quesada, V., Garabaya, C. and Lopez-Otin, C. Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. Proc Natl Acad Sci U S A1009185-90 (2003).  PubMed
Cadinanos, J., Schmidt, W. K., Fueyo, A., Varela, I., Lopez-Otin, C. and Freije, J. M. Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans. Biochem J3701047-54 (2003).  PubMed
Cadinanos, J., Varela, I., Mandel, D. A., Schmidt, W. K., Diaz-Perales, A., Lopez-Otin, C. and Freije, J. M. AtFACE-2, a functional prenylated protein protease from Arabidopsis thaliana related to mammalian Ras-converting enzymes. J Biol Chem27842091-7 (2003).  PubMed
Balbin, M., Fueyo, A., Tester, A. M., Pendas, A. M., Pitiot, A. S., Astudillo, A., Overall, C. M., Shapiro, S. D. and Lopez-Otin, C. Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nature Genet35252-7 (2003).  PubMed

2002

Zaragoza, C., Balbin, M., Lopez-Otin, C. and Lamas, S. Nitric oxide regulates matrix metalloprotease-13 expression and activity in endothelium. Kidney Int61804-8 (2002).  PubMed
Zaragoza, C., Soria, E., Lopez, E., Browning, D., Balbin, M., Lopez-Otin, C. and Lamas, S. Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells. Mol Pharmacol62927-35 (2002).  PubMed
Velasco, G., Cal, S., Quesada, V., Sanchez, L. M. and Lopez-Otin, C. Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins. J Biol Chem27737637-46 (2002).  PubMed
Pendas, A. M., Zhou, Z., Cadinanos, J., Freije, J. M., Wang, J., Hultenby, K., Astudillo, A., Wernerson, A., Rodriguez, F., Tryggvason, K. and Lopez-Otin, C. Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nature Genet3194-9 (2002).  PubMed
Overall, C. M. and Lopez-Otin, C. Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nature Rev Cancer2657-72 (2002).  PubMed
Lopez-Otin, C. and Overall, C. M. Protease degradomics: a new challenge for proteomics. Nature Rev Mol Cell Biol3509-19 (2002).  PubMed
Llano, E., Adam, G., Pendas, A. M., Quesada, V., Sanchez, L. M., Santamaria, I., Noselli, S. and Lopez-Otin, C. Structural and enzymatic characterization of Drosophila Dm2-MMP, a membrane-bound matrix metalloproteinase with tissue-specific expression. J Biol Chem27723321-9 (2002).  PubMed
Cal, S., Obaya, A. J., Llamazares, M., Garabaya, C., Quesada, V. and Lopez-Otin, C. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. Gene28349-62 (2002).  PubMed

2001

Velasco, G. and Lopez-Otin, C. Strategies for cloning new MMPs and TIMPs. Methods Mol Biol15125-44 (2001).  PubMed
Nielsen, B. S., Rank, F., Lopez, J. M., Balbin, M., Vizoso, F., Lund, L. R., Dano, K. and Lopez-Otin, C. Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas. Cancer Res617091-100 (2001).  PubMed
Jimenez, M. J., Balbin, M., Alvarez, J., Komori, T., Bianco, P., Holmbeck, K., Birkedal-Hansen, H., Lopez, J. M. and Lopez-Otin, C. A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation. J Cell Biol1551333-44 (2001).  PubMed
Engelholm, L. H., Nielsen, B. S., Netzel-Arnett, S., Solberg, H., Chen, X. D., Lopez Garcia, J. M., Lopez-Otin, C., Young, M. F., Birkedal-Hansen, H., Dano, K., Lund, L. R., Behrendt, N. and Bugge, T. H. The urokinase plasminogen activator receptor-associated protein/endo180 is coexpressed with its interaction partners urokinase plasminogen activator receptor and matrix metalloprotease-13 during osteogenesis. Lab Invest811403-14 (2001).  PubMed
Cal, S., Arguelles, J. M., Fernandez, P. L. and Lopez-Otin, C. Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats. J Biol Chem27617932-40 (2001).  PubMed
Balbin, M., Fueyo, A., Knauper, V., Lopez, J. M., Alvarez, J., Sanchez, L. M., Quesada, V., Bordallo, J., Murphy, G. and Lopez-Otin, C. Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. J Biol Chem27610253-62 (2001).  PubMed