Quesada, V., Ordonez, G. R., Sanchez, L. M., Puente, X. S. and Lopez-Otin, C. The Degradome database: mammalian proteases and diseases of proteolysis. Nucleic Acids Res, 37, D239-43 (2009). PubMed
Varela, I., Pereira, S., Ugalde, A. P., Navarro, C. L., Suarez, M. F., Cau, P., Cadinanos, J., Osorio, F. G., Foray, N., Cobo, J., de Carlos, F., Levy, N., Freije, J. M. and Lopez-Otin, C. Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging. Nature Med, 14, 767-72 (2008). PubMed
Platypus Sequencing and Analysis group (including Puente, X. S., Lopez-Otin, C., and Ordonez, G. R.) Genome analysis of the platypus reveals unique signatures of evolution. Nature, 453, 175-83 (2008). PubMed
Espada, J., Varela, I., Flores, I., Ugalde, A. P., Cadinanos, J., Pendas, A. M., Stewart, C. L., Tryggvason, K., Blasco, M. A., Freije, J. M. and Lopez-Otin, C. Nuclear envelope defects cause stem cell dysfunction in premature-aging mice. J Cell Biol, 181, 27-35 (2008). PubMed
Lopez-Otin, C. and Bond, J. S. Proteases: multifunctional enzymes in life and disease. J Biol Chem, 283, 30433-7 (2008). PubMed
Lopez-Otin, C. and Matrisian, L. M. Emerging roles of proteases in tumour suppression. Nature Rev Cancer, 7, 800-8 (2007). PubMed
Marino, G., Salvador-Montoliu, N., Fueyo, A., Knecht, E., Mizushima, N. and Lopez-Otin, C. Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem, 282, 18573-83 (2007). PubMed
Varela, I., Cadinanos, J., Pendas, A. M., Gutierrez-Fernandez, A., Folgueras, A. R., Sanchez, L. M., Zhou, Z., Rodriguez, F. J., Stewart, C. L., Vega, J. A., Tryggvason, K., Freije, J. M. and Lopez-Otin, C. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature, 437, 564-8 (2005). PubMed
Liu, B., Wang, J., Chan, K. M., Tjia, W. M., Deng, W., Guan, X., Huang, J. D., Li, K. M., Chau, P. Y., Chen, D. J., Pei, D., Pendas, A. M., Cadinanos, J., Lopez-Otin, C., Tse, H. F., Hutchison, C., Chen, J., Cao, Y., Cheah, K. S., Tryggvason, K. and Zhou, Z. Genomic instability in laminopathy-based premature aging. Nature Med, 11, 780-5 (2005). PubMed
Chimpanzee Sequencing and Analysis Consortium (including Puente, X. S., Velasco, G. & Lopez-Otin, C.) Initial sequence of the chimpanzee genome and comparison with the human genome. Nature, 437, 69-87 (2005). PubMed
Rat Sequencing and Analysis Consortium (including Puente, X. S., Velasco, G. & Lopez-Otin, C.) Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature, 428, 493-521 (2004). PubMed
Balbin, M., Fueyo, A., Tester, A. M., Pendas, A. M., Pitiot, A. S., Astudillo, A., Overall, C. M., Shapiro, S. D. and Lopez-Otin, C. Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nature Genet, 35, 252-7 (2003). PubMed
Puente, X. S., Sanchez, L. M., Overall, C. M. and Lopez-Otin, C. Human and mouse proteases: a comparative genomic approach. Nature Rev Genet, 4, 544-58 (2003). PubMed
Cal, S., Quesada, V., Garabaya, C. and Lopez-Otin, C. Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. Proc Natl Acad Sci U S A, 100, 9185-90 (2003). PubMed
Pendas, A. M., Zhou, Z., Cadinanos, J., Freije, J. M., Wang, J., Hultenby, K., Astudillo, A., Wernerson, A., Rodriguez, F., Tryggvason, K. and Lopez-Otin, C. Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nature Genet, 31, 94-9 (2002). PubMed
Lopez-Otin, C. and Overall, C. M. Protease degradomics: a new challenge for proteomics. Nature Rev Mol Cell Biol, 3, 509-19 (2002). PubMed
Overall, C. M. and Lopez-Otin, C. Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nature Rev Cancer, 2, 657-72 (2002). PubMed
Freije, J. M., Diez-Itza, I., Balbin, M., Sanchez, L. M., Blasco, R., Tolivia, J. and Lopez-Otin, C. Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas. J Biol Chem, 269, 16766-73 (1994). PubMed
Recent publications
2009
Osorio, F. G., Obaya, A. J., Lopez-Otin, C. and Freije, J. M. Accelerated ageing: from mechanism to therapy through animal models. Transgenic Res, 18, 7-15 (2009). PubMed
Quesada, V., Ordonez, G. R., Sanchez, L. M., Puente, X. S. and Lopez-Otin, C. The Degradome database: mammalian proteases and diseases of proteolysis. Nucleic Acids Res, 37, D239-43 (2009). PubMed
Ramsay, A. J., Hooper, J. D., Folgueras, A. R., Velasco, G. and Lopez-Otin, C. Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis. Haematologica, 94, 840-9 (2009). PubMed
Viloria, C. G., Obaya, A. J., Moncada-Pazos, A., Llamazares, M., Astudillo, A., Capella, G., Cal, S. and Lopez-Otin, C. Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer. Cancer Res, 69, 4926-34 (2009). PubMed
Moncada-Pazos, A., Obaya, A. J., Fraga, M. F., Viloria, C. G., Capella, G., Gausachs, M., Esteller, M., Lopez-Otin, C. and Cal, S. The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer. J Cell Sci, 122, 2906-13 (2009). PubMed
Alvarez-Diaz, S., Valle, N., Garcia, J. M., Pena, C., Freije, J. M., Quesada, V., Astudillo, A., Bonilla, F., Lopez-Otin, C. and Munoz, A. Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells. J Clin Invest, 119, 2343-58 (2009). PubMed
Ramsay, A. J., Quesada, V., Sanchez, M., Garabaya, C., Sarda, M. P., Baiget, M., Remacha, A., Velasco, G. and Lopez-Otin, C. Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms. Hum Mol Genet, 18, 3673-83 (2009). PubMed
Folgueras, A. R., Valdes-Sanchez, T., Llano, E., Menendez, L., Baamonde, A., Denlinger, B. L., Belmonte, C., Juarez, L., Lastra, A., Garcia-Suarez, O., Astudillo, A., Kirstein, M., Pendas, A. M., Farinas, I. and Lopez-Otin, C. Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation. Proc Natl Acad Sci U S A, 106, 16451-6 (2009). PubMed
Laxton, R. C., Hu, Y., Duchene, J., Zhang, F., Zhang, Z., Leung, K. Y., Xiao, Q., Scotland, R. S., Hodgkinson, C. P., Smith, K., Willeit, J., Lopez-Otin, C., Simpson, I. A., Kiechl, S., Ahluwalia, A., Xu, Q. and Ye, S. A role of matrix metalloproteinase-8 in atherosclerosis. Circ Res, 105, 921-9 (2009). PubMed
Lopez-Otin, C., Palavalli, L. H. and Samuels, Y. Protective roles of matrix metalloproteinases: from mouse models to human cancer. Cell Cycle, 8, 3657-62 (2009). PubMed
Ordonez, G. R., Puente, X. S., Quesada, V. and Lopez-Otin, C. Proteolytic systems: constructing degradomes. Methods Mol Biol, 539, 33-47 (2009). PubMed
2008
Varela, I., Pereira, S., Ugalde, A. P., Navarro, C. L., Suarez, M. F., Cau, P., Cadinanos, J., Osorio, F. G., Foray, N., Cobo, J., de Carlos, F., Levy, N., Freije, J. M. and Lopez-Otin, C. Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging. Nature Med, 14, 767-72 (2008). PubMed
Platypus Sequencing and Analysis group (including Puente, X. S., Lopez-Otin, C., and Ordonez, G. R.) Genome analysis of the platypus reveals unique signatures of evolution. Nature, 453, 175-83 (2008). PubMed
Ordonez, G. R., Hillier, L. W., Warren, W. C., Grutzner, F., Lopez-Otin, C. and Puente, X. S. Loss of genes implicated in gastric function during platypus evolution. Genome Biol, 9, R81 (2008). PubMed
Multiple authors (including Lopez-Otin, C. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy, 4, 151-75 (2008). PubMed
Marino, G., Ugalde, A. P., Salvador-Montoliu, N., Varela, I., Quiros, P. M., Cadinanos, J., van der Pluijm, I., Freije, J. M. and Lopez-Otin, C. Premature aging in mice activates a systemic metabolic response involving autophagy induction. Hum Mol Genet, 17, 2196-211 (2008). PubMed
Marino, G. and Lopez-Otin, C. Autophagy and aging: new lessons from progeroid mice. Autophagy, 4, 807-9 (2008). PubMed
Lopez-Otin, C. and Bond, J. S. Proteases: multifunctional enzymes in life and disease. J Biol Chem, 283, 30433-7 (2008). PubMed
Lizarbe, T. R., Garcia-Rama, C., Tarin, C., Saura, M., Calvo, E., Lopez, J. A., Lopez-Otin, C., Folgueras, A. R., Lamas, S. and Zaragoza, C. Nitric oxide elicits functional MMP-13 protein-tyrosine nitration during wound repair. Faseb J, 22, 3207-15 (2008). PubMed
Korpi, J. T., Kervinen, V., Maklin, H., Vaananen, A., Lahtinen, M., Laara, E., Ristimaki, A., Thomas, G., Ylipalosaari, M., Astrom, P., Lopez-Otin, C., Sorsa, T., Kantola, S., Pirila, E. and Salo, T. Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer. Br J Cancer, 98, 766-75 (2008). PubMed
Gutierrez-Fernandez, A., Fueyo, A., Folgueras, A. R., Garabaya, C., Pennington, C. J., Pilgrim, S., Edwards, D. R., Holliday, D. L., Jones, J. L., Span, P. N., Sweep, F. C., Puente, X. S. and Lopez-Otin, C. Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion. Cancer Res, 68, 2755-63 (2008). PubMed
Folgueras, A. R., Fueyo, A., Garcia-Suarez, O., Cox, J., Astudillo, A., Tortorella, P., Campestre, C., Gutierrez-Fernandez, A., Fanjul-Fernandez, M., Pennington, C. J., Edwards, D. R., Overall, C. M. and Lopez-Otin, C. Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice. J Biol Chem, 283, 9465-74 (2008). PubMed
Folgueras, A. R., de Lara, F. M., Pendas, A. M., Garabaya, C., Rodriguez, F., Astudillo, A., Bernal, T., Cabanillas, R., Lopez-Otin, C. and Velasco, G. Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis. Blood, 112, 2539-45 (2008). PubMed
Espada, J., Varela, I., Flores, I., Ugalde, A. P., Cadinanos, J., Pendas, A. M., Stewart, C. L., Tryggvason, K., Blasco, M. A., Freije, J. M. and Lopez-Otin, C. Nuclear envelope defects cause stem cell dysfunction in premature-aging mice. J Cell Biol, 181, 27-35 (2008). PubMed
2007
Van Roy, M., Van Lint, P., Van Laere, I., Wielockx, B., Wilson, C., Lopez-Otin, C., Shapiro, S. and Libert, C. Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNgamma-based cancer therapy in mice. Mol Cancer Ther, 6, 2563-71 (2007). PubMed
Tester, A. M., Cox, J. H., Connor, A. R., Starr, A. E., Dean, R. A., Puente, X. S., Lopez-Otin, C. and Overall, C. M. LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity. PLoS ONE, 2, e312 (2007). PubMed
Ramirez, C. L., Cadinanos, J., Varela, I., Freije, J. M. and Lopez-Otin, C. Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions. Cell Mol Life Sci, 64, 155-70 (2007). PubMed
Pirila, E., Korpi, J. T., Korkiamaki, T., Jahkola, T., Gutierrez-Fernandez, A., Lopez-Otin, C., Saarialho-Kere, U., Salo, T. and Sorsa, T. Collagenase-2 (MMP-8) and matrilysin-2 (MMP-26) expression in human wounds of different etiologies. Wound Repair Regen, 15, 47-57 (2007). PubMed
Marino, G., Salvador-Montoliu, N., Fueyo, A., Knecht, E., Mizushima, N. and Lopez-Otin, C. Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem, 282, 18573-83 (2007). PubMed
Lopez-Otin, C. and Matrisian, L. M. Emerging roles of proteases in tumour suppression. Nature Rev Cancer, 7, 800-8 (2007). PubMed
Llamazares, M., Obaya, A. J., Moncada-Pazos, A., Heljasvaara, R., Espada, J., Lopez-Otin, C. and Cal, S. The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway. J Cell Sci, 120, 3544-52 (2007). PubMed
Gutierrez-Fernandez, A., Inada, M., Balbin, M., Fueyo, A., Pitiot, A. S., Astudillo, A., Hirose, K., Hirata, M., Shapiro, S. D., Noel, A., Werb, Z., Krane, S. M., Lopez-Otin, C. and Puente, X. S. Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). Faseb J, 21, 2580-91 (2007). PubMed
Cal, S., Moncada-Pazos, A. and Lopez-Otin, C. Expanding the complexity of the human degradome: polyserases and their tandem serine protease domains. Front Biosci, 12, 4661-9 (2007). PubMed
2006
Puente, X. S., Velasco, G., Gutierrez-Fernandez, A., Bertranpetit, J., King, M. C. and Lopez-Otin, C. Comparative analysis of cancer genes in the human and chimpanzee genomes. BMC Genomics, 7, 15 (2006). PubMed
Jost, M., Folgueras, A. R., Frerart, F., Pendas, A. M., Blacher, S., Houard, X., Berndt, S., Munaut, C., Cataldo, D., Alvarez, J., Melen-Lamalle, L., Foidart, J. M., Lopez-Otin, C. and Noel, A. Earlier onset of tumoral angiogenesis in matrix metalloproteinase-19-deficient mice. Cancer Res, 66, 5234-41 (2006). PubMed
Hernandez, M., Valenzuela, M. A., Lopez-Otin, C., Alvarez, J., Lopez, J. M., Vernal, R. and Gamonal, J. Matrix metalloproteinase-13 is highly expressed in destructive periodontal disease activity. J Periodontol, 77, 1863-70 (2006). PubMed
Gonzalez, L., Freije, J. M., Cal, S., Lopez-Otin, C., Serrano, M. and Palmero, I. A functional link between the tumour suppressors ARF and p33ING1. Oncogene, 25, 5173-9 (2006). PubMed
Chabottaux, V., Sounni, N. E., Pennington, C. J., English, W. R., van den Brule, F., Blacher, S., Gilles, C., Munaut, C., Maquoi, E., Lopez-Otin, C., Murphy, G., Edwards, D. R., Foidart, J. M. and Noel, A. Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases. Cancer Res, 66, 5165-72 (2006). PubMed
Cal, S., Peinado, J. R., Llamazares, M., Quesada, V., Moncada-Pazos, A., Garabaya, C. and Lopez-Otin, C. Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain. BMC Biochem, 7, 9 (2006). PubMed
2005
Wang, X., Inoue, S., Gu, J., Miyoshi, E., Noda, K., Li, W., Mizuno-Horikawa, Y., Nakano, M., Asahi, M., Takahashi, M., Uozumi, N., Ihara, S., Lee, S. H., Ikeda, Y., Yamaguchi, Y., Aze, Y., Tomiyama, Y., Fujii, J., Suzuki, K., Kondo, A., Shapiro, S. D., Lopez-Otin, C., Kuwaki, T., Okabe, M., Honke, K. and Taniguchi, N. Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. Proc Natl Acad Sci U S A, 102, 15791-6 (2005). PubMed
Varela, I., Cadinanos, J., Pendas, A. M., Gutierrez-Fernandez, A., Folgueras, A. R., Sanchez, L. M., Zhou, Z., Rodriguez, F. J., Stewart, C. L., Vega, J. A., Tryggvason, K., Freije, J. M. and Lopez-Otin, C. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature, 437, 564-8 (2005). PubMed
Van Lint, P., Wielockx, B., Puimege, L., Noel, A., Lopez-Otin, C. and Libert, C. Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis. J Immunol, 175, 7642-9 (2005). PubMed
Tao, Z., Peng, Y., Nolasco, L., Cal, S., Lopez-Otin, C., Li, R., Moake, J. L., Lopez, J. A. and Dong, J. F. Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions. Blood, 106, 4139-45 (2005). PubMed
Puente, X. S., Sanchez, L. M., Gutierrez-Fernandez, A., Velasco, G. and Lopez-Otin, C. A genomic view of the complexity of mammalian proteolytic systems. Biochem Soc Trans, 33, 331-4 (2005). PubMed
Puente, X. S., Gutierrez-Fernandez, A., Ordonez, G. R., Hillier, L. W. and Lopez-Otin, C. Comparative genomic analysis of human and chimpanzee proteases. Genomics, 86, 638-47 (2005). PubMed
Navarro, C. L., Cadinanos, J., De Sandre-Giovannoli, A., Bernard, R., Courrier, S., Boccaccio, I., Boyer, A., Kleijer, W. J., Wagner, A., Giuliano, F., Beemer, F. A., Freije, J. M., Cau, P., Hennekam, R. C., Lopez-Otin, C., Badens, C. and Levy, N. Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors. Hum Mol Genet, 14, 1503-13 (2005). PubMed
Liu, B., Wang, J., Chan, K. M., Tjia, W. M., Deng, W., Guan, X., Huang, J. D., Li, K. M., Chau, P. Y., Chen, D. J., Pei, D., Pendas, A. M., Cadinanos, J., Lopez-Otin, C., Tse, H. F., Hutchison, C., Chen, J., Cao, Y., Cheah, K. S., Tryggvason, K. and Zhou, Z. Genomic instability in laminopathy-based premature aging. Nature Med, 11, 780-5 (2005). PubMed
Levy, N., Lopez-Otin, C. and Hennekam, R. C. Defective prelamin A processing resulting from LMNA or ZMPSTE24 mutations as the cause of restrictive dermopathy. Arch Dermatol, 141, 1473-4; author reply 1474 (2005). PubMed
Kennedy, A. M., Inada, M., Krane, S. M., Christie, P. T., Harding, B., Lopez-Otin, C., Sanchez, L. M., Pannett, A. A., Dearlove, A., Hartley, C., Byrne, M. H., Reed, A. A., Nesbit, M. A., Whyte, M. P. and Thakker, R. V. MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO). J Clin Invest, 115, 2832-42 (2005). PubMed
Gueders, M. M., Balbin, M., Rocks, N., Foidart, J. M., Gosset, P., Louis, R., Shapiro, S., Lopez-Otin, C., Noel, A. and Cataldo, D. D. Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J Immunol, 175, 2589-97 (2005). PubMed
Diaz-Perales, A., Quesada, V., Sanchez, L. M., Ugalde, A. P., Suarez, M. F., Fueyo, A. and Lopez-Otin, C. Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase. J Biol Chem, 280, 14310-7 (2005). PubMed
Diaz-Perales, A., Quesada, V., Peinado, J. R., Ugalde, A. P., Alvarez, J., Suarez, M. F., Gomis-Ruth, F. X. and Lopez-Otin, C. Identification and characterization of human archaemetzincin-1 and -2, two novel members of a family of metalloproteases widely distributed in Archaea. J Biol Chem, 280, 30367-75 (2005). PubMed
Chimpanzee Sequencing and Analysis Consortium (including Puente, X. S., Velasco, G. & Lopez-Otin, C.) Initial sequence of the chimpanzee genome and comparison with the human genome. Nature, 437, 69-87 (2005). PubMed
Cal, S., Quesada, V., Llamazares, M., Diaz-Perales, A., Garabaya, C. and Lopez-Otin, C. Human polyserase-2, a novel enzyme with three tandem serine protease domains in a single polypeptide chain. J Biol Chem, 280, 1953-61 (2005). PubMed
Cadinanos, J., Varela, I., Lopez-Otin, C. and Freije, J. M. From immature lamin to premature aging: molecular pathways and therapeutic opportunities. Cell Cycle, 4, 1732-5 (2005). PubMed
Appenzeller-Herzog, C., Nyfeler, B., Burkhard, P., Santamaria, I., Lopez-Otin, C. and Hauri, H. P. Carbohydrate- and conformation-dependent cargo capture for ER-exit. Mol Biol Cell, 16, 1258-67 (2005). PubMed
2004
Sabeh, F., Ota, I., Holmbeck, K., Birkedal-Hansen, H., Soloway, P., Balbin, M., Lopez-Otin, C., Shapiro, S., Inada, M., Krane, S., Allen, E., Chung, D. and Weiss, S. J. Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP. J Cell Biol, 167, 769-81 (2004). PubMed
Rat Sequencing and Analysis Consortium (including Puente, X. S., Velasco, G. & Lopez-Otin, C.) Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature, 428, 493-521 (2004). PubMed
Rasmussen, F. H., Yeung, N., Kiefer, L., Murphy, G., Lopez-Otin, C., Vitek, M. P. and Moss, M. L. Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases. Biochemistry, 43, 2987-95 (2004). PubMed
Quesada, V., Diaz-Perales, A., Gutierrez-Fernandez, A., Garabaya, C., Cal, S. and Lopez-Otin, C. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Biochem Biophys Res Commun, 314, 54-62 (2004). PubMed
Quesada, V., Sanchez, L. M., Alvarez, J. and Lopez-Otin, C. Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish. J Biol Chem, 279, 26627-34 (2004). PubMed
Puente, X. S. and Lopez-Otin, C. A genomic analysis of rat proteases and protease inhibitors. Genome Res, 14, 609-22 (2004). PubMed
Pendas, A. M., Folgueras, A. R., Llano, E., Caterina, J., Frerard, F., Rodriguez, F., Astudillo, A., Noel, A., Birkedal-Hansen, H. and Lopez-Otin, C. Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient mice. Mol Cell Biol, 24, 5304-13 (2004). PubMed
Owen, C. A., Hu, Z., Lopez-Otin, C. and Shapiro, S. D. Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase. J Immunol, 172, 7791-803 (2004). PubMed
Overall, C. M., Tam, E. M., Kappelhoff, R., Connor, A., Ewart, T., Morrison, C. J., Puente, X., Lopez-Otin, C. and Seth, A. Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors. Biol Chem, 385, 493-504 (2004). PubMed
Marino, G. and Lopez-Otin, C. Autophagy: molecular mechanisms, physiological functions and relevance in human pathology. Cell Mol Life Sci, 61, 1439-54 (2004). PubMed
Inada, M., Wang, Y., Byrne, M. H., Rahman, M. U., Miyaura, C., Lopez-Otin, C. and Krane, S. M. Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A, 101, 17192-7 (2004). PubMed
Folgueras, A. R., Pendas, A. M., Sanchez, L. M. and Lopez-Otin, C. Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies. Int J Dev Biol, 48, 411-24 (2004). PubMed
Bister, V. O., Salmela, M. T., Karjalainen-Lindsberg, M. L., Uria, J., Lohi, J., Puolakkainen, P., Lopez-Otin, C. and Saarialho-Kere, U. Differential expression of three matrix metalloproteinases, MMP-19, MMP-26, and MMP-28, in normal and inflamed intestine and colon cancer. Dig Dis Sci, 49, 653-61 (2004). PubMed
2003
Zucker, S., Pei, D., Cao, J. and Lopez-Otin, C. Membrane type-matrix metalloproteinases (MT-MMP). Curr Top Dev Biol, 54, 1-74 (2003). PubMed
Puente, X. S., Sanchez, L. M., Overall, C. M. and Lopez-Otin, C. Human and mouse proteases: a comparative genomic approach. Nature Rev Genet, 4, 544-58 (2003). PubMed
Marino, G., Uria, J. A., Puente, X. S., Quesada, V., Bordallo, J. and Lopez-Otin, C. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. J Biol Chem, 278, 3671-8 (2003). PubMed
Llamazares, M., Cal, S., Quesada, V. and Lopez-Otin, C. Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain. J Biol Chem, 278, 13382-9 (2003). PubMed
Hieta, N., Impola, U., Lopez-Otin, C., Saarialho-Kere, U. and Kahari, V. M. Matrix metalloproteinase-19 expression in dermal wounds and by fibroblasts in culture. J Invest Dermatol, 121, 997-1004 (2003). PubMed
Freije, J. M., Balbin, M., Pendas, A. M., Sanchez, L. M., Puente, X. S. and Lopez-Otin, C. Matrix metalloproteinases and tumor progression. Adv Exp Med Biol, 532, 91-107 (2003). PubMed
Cal, S., Quesada, V., Garabaya, C. and Lopez-Otin, C. Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. Proc Natl Acad Sci U S A, 100, 9185-90 (2003). PubMed
Cadinanos, J., Schmidt, W. K., Fueyo, A., Varela, I., Lopez-Otin, C. and Freije, J. M. Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans. Biochem J, 370, 1047-54 (2003). PubMed
Cadinanos, J., Varela, I., Mandel, D. A., Schmidt, W. K., Diaz-Perales, A., Lopez-Otin, C. and Freije, J. M. AtFACE-2, a functional prenylated protein protease from Arabidopsis thaliana related to mammalian Ras-converting enzymes. J Biol Chem, 278, 42091-7 (2003). PubMed
Balbin, M., Fueyo, A., Tester, A. M., Pendas, A. M., Pitiot, A. S., Astudillo, A., Overall, C. M., Shapiro, S. D. and Lopez-Otin, C. Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nature Genet, 35, 252-7 (2003). PubMed
2002
Zaragoza, C., Balbin, M., Lopez-Otin, C. and Lamas, S. Nitric oxide regulates matrix metalloprotease-13 expression and activity in endothelium. Kidney Int, 61, 804-8 (2002). PubMed
Zaragoza, C., Soria, E., Lopez, E., Browning, D., Balbin, M., Lopez-Otin, C. and Lamas, S. Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells. Mol Pharmacol, 62, 927-35 (2002). PubMed
Velasco, G., Cal, S., Quesada, V., Sanchez, L. M. and Lopez-Otin, C. Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins. J Biol Chem, 277, 37637-46 (2002). PubMed
Pendas, A. M., Zhou, Z., Cadinanos, J., Freije, J. M., Wang, J., Hultenby, K., Astudillo, A., Wernerson, A., Rodriguez, F., Tryggvason, K. and Lopez-Otin, C. Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nature Genet, 31, 94-9 (2002). PubMed
Overall, C. M. and Lopez-Otin, C. Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nature Rev Cancer, 2, 657-72 (2002). PubMed
Lopez-Otin, C. and Overall, C. M. Protease degradomics: a new challenge for proteomics. Nature Rev Mol Cell Biol, 3, 509-19 (2002). PubMed
Llano, E., Adam, G., Pendas, A. M., Quesada, V., Sanchez, L. M., Santamaria, I., Noselli, S. and Lopez-Otin, C. Structural and enzymatic characterization of Drosophila Dm2-MMP, a membrane-bound matrix metalloproteinase with tissue-specific expression. J Biol Chem, 277, 23321-9 (2002). PubMed
Cal, S., Obaya, A. J., Llamazares, M., Garabaya, C., Quesada, V. and Lopez-Otin, C. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. Gene, 283, 49-62 (2002). PubMed
2001
Velasco, G. and Lopez-Otin, C. Strategies for cloning new MMPs and TIMPs. Methods Mol Biol, 151, 25-44 (2001). PubMed
Nielsen, B. S., Rank, F., Lopez, J. M., Balbin, M., Vizoso, F., Lund, L. R., Dano, K. and Lopez-Otin, C. Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas. Cancer Res, 61, 7091-100 (2001). PubMed
Jimenez, M. J., Balbin, M., Alvarez, J., Komori, T., Bianco, P., Holmbeck, K., Birkedal-Hansen, H., Lopez, J. M. and Lopez-Otin, C. A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation. J Cell Biol, 155, 1333-44 (2001). PubMed
Engelholm, L. H., Nielsen, B. S., Netzel-Arnett, S., Solberg, H., Chen, X. D., Lopez Garcia, J. M., Lopez-Otin, C., Young, M. F., Birkedal-Hansen, H., Dano, K., Lund, L. R., Behrendt, N. and Bugge, T. H. The urokinase plasminogen activator receptor-associated protein/endo180 is coexpressed with its interaction partners urokinase plasminogen activator receptor and matrix metalloprotease-13 during osteogenesis. Lab Invest, 81, 1403-14 (2001). PubMed
Cal, S., Arguelles, J. M., Fernandez, P. L. and Lopez-Otin, C. Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats. J Biol Chem, 276, 17932-40 (2001). PubMed
Balbin, M., Fueyo, A., Knauper, V., Lopez, J. M., Alvarez, J., Sanchez, L. M., Quesada, V., Bordallo, J., Murphy, G. and Lopez-Otin, C. Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. J Biol Chem, 276, 10253-62 (2001). PubMed
2000
Velasco, G. and Lopez-Otin, C. Strategies for cloning new MMPs and TIMPs. Methods Mol Biol, 151, 25-44 (2001). PubMed
Nielsen, B. S., Rank, F., Lopez, J. M., Balbin, M., Vizoso, F., Lund, L. R., Dano, K. and Lopez-Otin, C. Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas. Cancer Res, 61, 7091-100 (2001). PubMed
Jimenez, M. J., Balbin, M., Alvarez, J., Komori, T., Bianco, P., Holmbeck, K., Birkedal-Hansen, H., Lopez, J. M. and Lopez-Otin, C. A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation. J Cell Biol, 155, 1333-44 (2001). PubMed
Engelholm, L. H., Nielsen, B. S., Netzel-Arnett, S., Solberg, H., Chen, X. D., Lopez Garcia, J. M., Lopez-Otin, C., Young, M. F., Birkedal-Hansen, H., Dano, K., Lund, L. R., Behrendt, N. and Bugge, T. H. The urokinase plasminogen activator receptor-associated protein/endo180 is coexpressed with its interaction partners urokinase plasminogen activator receptor and matrix metalloprotease-13 during osteogenesis. Lab Invest, 81, 1403-14 (2001). PubMed
Cal, S., Arguelles, J. M., Fernandez, P. L. and Lopez-Otin, C. Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats. J Biol Chem, 276, 17932-40 (2001). PubMed
Balbin, M., Fueyo, A., Knauper, V., Lopez, J. M., Alvarez, J., Sanchez, L. M., Quesada, V., Bordallo, J., Murphy, G. and Lopez-Otin, C. Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. J Biol Chem, 276, 10253-62 (2001). PubMed